[The role of ghrelin in the regulation of energy homeostasis]
Journal Title: Endokrynologia, Diabetologia i Choroby Przemiany Materii Wieku Rozwojowego - Year 2005, Vol 11, Issue 1
Abstract
Ghrelin, a novel 28 amino acid peptide, is the endogenous ligand for the growth hormone secretagogue receptor. The stomach is the primary source of circulating ghrelin, but it is also produced by the intestines, kidneys, hypothalamus, pituitary, placenta and pancreas. Ghrelin has been recognized as an important regulator of GH secretion and have important roles in energy homeostasis, glucose and lipid metabolism, reproduction, cardiovascular function, and immunity. Ghrelin has been shown to have a physiological role in the control of food intake, acting as an orexigenic hormone, probably by stimulating NPY production in contrast to the actions of leptin.
Authors and Affiliations
Ewa Otto Buczkowska
Keywords
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