The Role of Nitric Oxide (NO) in Shell of Left Nucleu Accumbense on Learning and Memory in Stress Condition Induced by Electrical Foot Shock in Male Wistar Rats
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Introduction: Any extrinsic or intrinsic stimulus that evokes a biological response is known as stress. In this case, the body's homeostatic mechanisms are activated to compensate for the conditions created with prolonged stress conditions, the biological systems are entering a chronic stressed phase. Nitric oxide (NO) is one of the important compounds that plays a role in stabilizing and prolonging neurotransmission in stress conditions. The aim of the present study was to investigate the effects of intra-accumbal injection of NO regulators, including L-Arginine (NO precursor) and L-NAME (NO inhibitor) on the learning, memory and metabolic alterations of the stressed male rats. Method: Animals were randomly devided into fifteen groups and every group was eight. In fourteen group intraaccumbal (shell of nucleus accumbens) cannulation was performed carefully. After recovery, the animals received four days of electric shock stress from the soles of the feet for 60 seconds. Five minutes before each stress period, three doses of L-NAME or L-Arginine were injected in to the shell of nucleus accumbense in doses 1,5,10 µg/kg and then the animals were tested. Subsequently, plasma cortisol levels and spatial memory of the animals were assessed by ELISA and Barnes Maze, respectively. Results: The results showed that stress alone caused a significant increase in plasma corticostron levels on the fourth day. 1µg dose of L-Arginine and L-NAME had opposite effects on corticostron concentration. Although 10 µg/kg dose of both drugs had similar effects on plasma corticostron concentration. In the early stages, stress reduced the number of errors in finding the target chamber and improved short-term memory. L-Arginine, especially at 1 µg/kg dose improves learning and enhances both short-term memories in stress condition and long-term memories in non-stress condition, but L-NAME Leads to the destruction of learning and prevents memory formation in stress-free situations. Conclusion: It can be concluded that L-Arginine enhances memory while L-NAME impairs learning and memory.
Authors and Affiliations
Y. Hosseini, F. Hosseini
Keywords
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- EP ID EP677915
- DOI 10.29088/GCNR-2020.06
- Views 262
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