The role of oxidation-reduction mechanismsin pathogenesis of thyroid orbitopathy
Journal Title: Annales Academiae Medicae Silesiensis - Year 2019, Vol 73, Issue
Abstract
Oxygen in the human body functions as a transmitter regulating cell bioenergetics and as a substrate in oxidation--reduction reactions, contributing to the formation of highly reactive oxygen species (ROS). The body’s antioxidant defense mechanisms include enzymatic and non-enzymatic systems. Graves’ disease, the underlying cause of which is the autoimmune process, is the most common cause of hyperthyroidism. The most common of the non-thyroid symptoms is orbital tissue inflammation called thyroid orbitopathy (TO). Under physiological conditions, there is a balance between the production of ROS and antioxidant activity. Disruption of this balance may lead to the development of oxidative stress. The article presents a review of the literature on oxidative-reduction processes in TO.
Authors and Affiliations
Olga Łach, Jakub Wojnarowicz, Mariusz Nowak
Keywords
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- EP ID EP611579
- DOI 10.18794/aams/105900
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