The role of polymorphonuclear granulocytes in transplanted kidney ischemia-reperfusion injury development.
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 3
Abstract
Ischemia-reperfusion injury (I/R injury) is a non-specific, antigen-independent tissue-destructive process affecting both early and long-term function of the allograft. Existing studies amply document pathophysiology of I/R injury and attribute it largely to neutrophil activation. Both experimental and clinical data confirm that a consistent feature of tissue injury following ischemia and reperfusion is acute inflammatory response with neutrophil infiltration and activation of vascular endothelium. Neutrophils (PMNs) are mediators of I/R injury following deceased-donor renal transplantation (kTx). The mechanism of tissue destruction by neutrophils involves production of reactive oxygen metabolites as well as secretion of proteolytic enzymes, such as serine proteases.
Authors and Affiliations
Małgorzata Zynek-Litwin, Jakub Kuźniar, Marian Klinger
Keywords
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