The role of thyroid hormones in the formation mechanisms of motor-secretory disorders in patients with gastroesophageal reflux disease with concomitant autoimmune thyroiditis
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 4
Abstract
Objective — to study the role of thyroid hormones in the formation of motor-secretory disorders with the comorbid course of gastroesophageal reflux disease (GERD) and autoimmune thyroiditis (AIT). Materials and methods. The examinations involved two groups of patients: the first group consisted of 25 patients (15 women and 10 men, aged 18 to 25 years) suffering from isolated GERD; the second group included 23 patients (12 women and 11 men aged from 19 to 25 years) with the combination of GERD and AIT. The control group consisted of 15 practically healthy persons, age- and gender-matching. All patients underwent a comprehensive examination according to the protocols for diagnosis and treatment of GERD (No 943 dated October 31, 2013) and AIT, as well as ultrasound examination of the motor-evacuation function of the esophagus and stomach with water loading. The intragastric method of pH-metry was performed to evaluate the stomach secretory function. The functional activity of the thyroid gland was determined by the ELISA method of the thyroid hormone level (TTG, T4 free, T3) and the presence of antibodies to thyroid peroxidase. Results. It has been established that in patients with GERD and AIT against the background of hyperthyroidism, there was a significant increase in the indices of gastric juice aggression with a simultaneous decrease in the parameters of alkalizing function antrum compared with the patients with isolated GERD. While the picture of AIT against the background of hypothyroidism was inversely proportional. It has been also shown that in patients with GERD with concomitant AIT against the background of hyperthyroidism, the hypertension of the stomach wall was noted, while in AIT against the background of hypofunction was noted a decrease in the tone of the stomach and lower esophageal sphincter. Conclusions. The clear correlation has been established between the indicators of gastrointestinal motor-secretory function, peculiarities of the clinical course and thyroid hormones’ levels, indicating the role of thyroid hormones in the formation of motor-secretory disorders at GERD.
Authors and Affiliations
O. A. Oparin, N. A. Yarantseva
Keywords
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- EP ID EP417389
- DOI 10.30978/MG-2018-3-25
- Views 122
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