The Sensitivity Of 99m Tc-Ciprofloxacin (Infecton) Scintigraphy Imaging To Detect Infection Lesions Induced By Staphylococcus Aureus Susceptible Or Resistant To Ciprofloxacin Antibiotic In Foot’s Rat
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 12
Abstract
The main propose of this approach is to evaluate the efficiency of 99mTc-Ciprofloxacin (Infecton) imaging to detect infection sites induced in foot’s rat by staphylococcus aureus susceptible to ciprofloxacin in comparison with S aureus resistant to drug. S aureus bacteria have been isolated from the patients admitted in Imam Khomeini hospital Ahvaz Khuzestan Iran. According to the table of Clinical and Laboratory Standards Institute (CLSI) the sensitivity or resistant of bacteria to ciprofloxacin was determined. Susceptible or resistant bacteria to ciprofloxacin selected and separated. A total number of forty six adult, Male NMRI rats were chosen. The animals were divided into two groups. Infection lesion in foot’s rat was induced by S aureus susceptible or resistant to ciprofloxacin respectively. The 37 MBq (1 mCi) 99mTc-Infecton administrated intravenously to each animal. Qualitative and quantitative studies have been performed. Infection sites induced by S aureus susceptible to quinolone could be observed and visualized by 99mTc-Infecton scintigraphy imaging. Qualitative and quantitative assessment indicated that radiotracer has not accumulated at the infection foci induced by S aureus resistant to ciprofloxacin antibiotic agent. Outcome of our assessment indicated that 99mTcCiproflixacin scintigraphy imaging study does not have any value to detect infection, if the bacteria involve in pathogenesis of induced infection lesions are resistant to ciprofloxacin. This study could demonstrate successfully that 99m Tc-Ciproflixacin scintigraphy imaging study can be suggested as an alternative method for investigation of sensitivity or resistant S aureus to ciprofloxacin antibiotic in clinical practice.
Authors and Affiliations
A. Doroudi , M. Erfani 2 , M. Rahmatian 1 , S. M. Saadati 3 , F. Ahmadi 3 ,A. Kiasat 3 ,M. J. Khodayar 1 , H. Meghdadi 4 and S. Rezaee
Keywords
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