The study of the kinetics of drying natural zeolite granules in a tray dryer
Journal Title: Вісник фармації - Year 2018, Vol 93, Issue 1
Abstract
Determination of the main drying parameters for choosing the optimal ones is obligatory when developing the drug technology, which uses wet granulation operations. Aim. To study the drying process of natural zeolite granules obtained by the wet granulation in a tray dryer for substantiation of its optimal modes. Materials and methods. The objects of the study were granules of natural zeolite with the size of 0.5-1.0 mm obtained by wet granulation using a NG-12 laboratory granulator made by Mariupol factory of technological equipment. As a binder 7 % starch paste added to the granulated mass in the amount of 25 % was used. The drying process was carried out in a tray dryer at the temperatures of 50, 60, 70, 80, 90 and 100 °C. Duration of the drying process was 5, 10, 15, 20, 25, 30, 40, 50, 60, 70, 80 and 90 min. Determination of the moisture content of granules was carried out by the weight loss when drying. The moisture content (gram of water/gram of a dry material) was determined taking into account the difference in mass before and after drying. The drying rate was determined by the amount of moisture removed from unit surface per unit time. Results and discussion. The study of kinetics of drying natural zeolite granules has shown that the rate of the process depends on the moisture content of the material, the level and duration of the temperature effect on the experimental objects. The optimal drying time for natural zeolite granules in a tray dryer and similar apparatuses by design and functionality is 25-30 min, and the optimal temperature mode is 60-80 °C. Conclusions. The kinetics and basic parameters of drying of natural zeolite granules obtained by the wet granulation method in a tray dryer have been studied. The optimal temperature and time modes of drying have been determined. The data obtained can be used when developing the technology of granules and tablets with natural zeolite.
Authors and Affiliations
V. D. Rybachuk, O. A. Ruban
Keywords
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- EP ID EP662484
- DOI 10.24959/nphj.18.2193
- Views 116
- Downloads 0
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