Development of methods for identification and quantitative determination of active substances in the medicated cosmetic cream for use in trichology
Journal Title: Вісник фармації - Year 2018, Vol 93, Issue 1
Abstract
To prevent and treat androgenic alopecia (AA) a medicated cosmetic cream (MCC) with the saw palmetto extract and the Sophora japonica tincture has been developed. The introduction of MCC in production requires its standardization and development of its quality control methods. Aim. To determine the qualitative composition and quantitative content of biologically active substances (BAS) in МСС for prevention and complex treatment of AA. Materials and methods. The study object was the experimental MCC with the saw palmetto extract and the Sophora japonica tincture. The qualitative reactions and the method of adsorption spectrometry (MAS) were proposed for BAS identification and quantitative determination. Results and discussion. During the study flavonoids and phytosterols were identified. The content of flavonoids calculated with reference to rutin was determined using MAS, it was 1.85 mg/g of МСС. The quantitative content of the amount of triglycerides and phytosterols calculated with reference to β-amirine was 3.59 mg/g of МСС. Conclusions. The qualitative reactions have been chosen to identify flavonoids for the Sophora japonica tincture and phytosterols for the saw palmetto extract; the conditions for identification and quantitative determination of BAS by MAS have been proposed. The methods developed will be used in the draft of Quality Control Methods (QCM) for MCC for prevention and complex treatment of AA.
Authors and Affiliations
M. I. Fedorovska, N. P. Polovko, V. O. Grudko
Keywords
Related Articles
- EP ID EP662490
- DOI 10.24959/nphj.18.2199
- Views 102
- Downloads 0
The study of the state of pharmaceutical provision for patients with cardiovascular diseases using ABC- and VEN-analyses
Aim. To assess the state of pharmaceutical provision for patients with cardiovascular diseases (CVD) using ABC, VEN and complex ABC/VEN analyses.Materials and methods. The study was performed according to the data of the...
Вивчення біофармацевтичних і адгезійних характеристик стоматологічного гелю
Значна поширеність стоматологічних патологій серед різних вікових груп населення Ук-раїни диктує необхідність пошуку нових ефективних лікарських засобів, що застосовуються в терапії захворювань ротової порожнини. Важливе...
Комплексный анализ назначений лекарственных средств для лечения сердечно-сосудистых заболеваний в стационарных условиях
Цель работы – комплексная оценка реального применения лекарственных средств для лечения сердечно-сосудистой системы в стационарных условиях, стоимость которых подлежит государственному возмещению. Материалы и методы. Мат...
Синтез и исследование антиоксидантной и противовоспалительной активности моно- и бис-производных спиро-2-оксиндол[3,3’]пиррола
Цель работы – синтез ряда моно- и бис-производных спиро-2-оксиндол[3,3’]пиррола и исследование их антиоксидантной и противовоспалительной активности. Материалы и методы. Методы органического синтеза, инструментальные мет...
The analysis of the pharmaceutical component of the emergency medical care system in Ukraine
Aim. To determine the role of the pharmaceutical component of emergency medical care in Ukraine. Materials and methods. Methods of information search, content-analysis, methods of comparison and generalization were used...