THE SYNERGISTIC EFFECT OF ETHANOL LEAF EXTRACT OF ANNONA MURICATA AND ARTOCARPUS HETEROPHYLLUS ON HIGH FAT DIET INDUCED HYPERLIPIDAEMIA IN WISTAR ALBINO RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 12
Abstract
The antihyperlipidaemic and antihypertensive effects of ethanol leaf extract of Annona muricata, Artocarpus heterophyllus and combined ethanol leaf extract of Annona muricata and Artocarpus heterophyllus on male wistar albino rats were studied. Forty eight (48) rats were given high fat diet (HFD) to induce hyperlipidaemia. The rats were treated with 200mg/kg body weight of A. muricata and A. heterophyllus, 100 and 200mg/kg body weight of combined ethanol leaf extract of A. muricata and A. heterophyllus. Ethanol leaf extract of A. muricata and A. heterophyllus had a positive effect on the total cholesterol, triglyceride, and high density lipoprotein level of the diabetic rats. The effects of the combined ethanol leaf extract on the heart tissue oxidative stress markers of the rats were also studied. A decrease which is statistically significant at p<0.05 was observed in the malondialdehyde level (0.50±0.07 μmol/ml) of the research animals. The result showed that ethanol leaf extract of A. muricata and A. heterophyllus with their combined extract had antihyperlipidaemic effect on high fat diet-induced hyperlipidaemia in wistar albino rats.
Authors and Affiliations
C. L. Onuah
Keywords
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