THE SYNERGISTIC EFFECT OF ETHANOL LEAF EXTRACT OF ANNONA MURICATA AND ARTOCARPUS HETEROPHYLLUS ON HIGH FAT DIET INDUCED HYPERLIPIDAEMIA IN WISTAR ALBINO RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 12
Abstract
The antihyperlipidaemic and antihypertensive effects of ethanol leaf extract of Annona muricata, Artocarpus heterophyllus and combined ethanol leaf extract of Annona muricata and Artocarpus heterophyllus on male wistar albino rats were studied. Forty eight (48) rats were given high fat diet (HFD) to induce hyperlipidaemia. The rats were treated with 200mg/kg body weight of A. muricata and A. heterophyllus, 100 and 200mg/kg body weight of combined ethanol leaf extract of A. muricata and A. heterophyllus. Ethanol leaf extract of A. muricata and A. heterophyllus had a positive effect on the total cholesterol, triglyceride, and high density lipoprotein level of the diabetic rats. The effects of the combined ethanol leaf extract on the heart tissue oxidative stress markers of the rats were also studied. A decrease which is statistically significant at p<0.05 was observed in the malondialdehyde level (0.50±0.07 μmol/ml) of the research animals. The result showed that ethanol leaf extract of A. muricata and A. heterophyllus with their combined extract had antihyperlipidaemic effect on high fat diet-induced hyperlipidaemia in wistar albino rats.
Authors and Affiliations
C. L. Onuah
Keywords
Related Articles
- EP ID EP627659
- DOI -
- Views 100
- Downloads 0
INTRANASAL ROUTE-AN INNOVATIVE TECHNIQUE FOR BRAIN TARGETTING
The complex arrangement of Blood-Brain Barrier(BBB) restricts the entry of drugs into the brain. The intranasal route is widely accepted route for the delivery of many therapeutic agents due to a reason it bypasses BBB....
CHANGES IN ELECTROLYTE IONS LEVEL IN HEALTHY AND OSTEOPOROSIS WOMEN IN BASRA PROVINCE / IRAQ
Osteoporosis is the most common bone disease in humans, it is characterized by low bone mass, deterioration of bone tissue and disruption of bone architecture, compromised bone strength and an increase in the risk of fra...
PREVENTION OF CARDIOVASCULAR DISEASE IN WOMEN: ROLE OF THE OBSTETRICIAN-GYNECOLOGIST
A qualitative study was conducted to understand the current and potential role of the community obstetrician gynecologist in risk factor screening and prevention of cardiovascular disease. A total of four focus group dis...
A REVIEW ON SIDDHA HERBAL FORMULATION DEVA CHOORANAM FOR IMPROVING THE QOL IN ACQUIRED IMMUNO DEFICIENCY SYNDROME (AIDS)
The ancient Siddha system of medicine has its origin right from the genesis of mankind. According to this medical system, herbs and human have proved their inseparable unification time and again all through the ages. Eit...
USING SOCIAL MEDIA TO CHALLENGE THE PERCEPTION OF DENTISTRY IN SAUDI ARABIA
Oral Health Problems are highly prevalent in most of the regions Saudi Arabia. There have been several studies conducted locally to conclude the nature and degree of oral health problems in the provinces. Several surveys...