THE THE TERATOGENIC EFFECTS OF ETHANOLIC EXTRACT OF BINTANGUR LEAVES (CALOPHYLLUM SOULATTRI BURM. F) ON FEMALE WHITE RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 8
Abstract
Objectives: Drugs can cause undesired effects on the fetus during pregnancy, especially embryonic/organogenesis which could lead to defects in the fetus because some types of drugs can penetrate the placenta and will undergo biotransformation into a highly reactive compound that has the potential to become a teratogenic compound. The aim of this research was to examine the teratogenic effect of bintangur leaves (Calophyllum soulattri Burm. F) ethanol extract to Sprague Dawley strain white rats. Methods: The white rats are divided into four treatment groups: Control group was given carboxymethyl cellulose Na 1%, comparison group was given trimethoprim 360 mg/kg BW, C. soulattri leaves ethanol extract (CLE) 100 mg/kg BW, and CLE 500 mg/kg BW. The treatment was administrated since organogenesis period. Cesarian section was performed to pregnant rat at the 20th day to separate the fetuses. Observation covered body weight of pregnant rats, fetal biometric, morphological malformation, and skeletal formation. Results: CLE 100 mg/kg BW and 500 mg/kg BW did not cause any change in the number of a living fetus, body weight, and length of fetuses like the comparison group. Both doses of CLE shown have a normal skeletal formation. Resorption was found in the comparison group and CLE 100 mg/kg BW with the percentage was 65.21% and 6.67%. It was found that there is no significant difference (p<0.05) between both doses of CLE compared to control group. Conclusion: From the results, it is concluded that CLE did not have the teratogenic effect.
Authors and Affiliations
INARAH FAJRIATY , HAFRIZAL RIZA , FAJAR NUGRAHA , FRENGKI FRIANTO
Keywords
Related Articles
- EP ID EP636152
- DOI -
- Views 97
- Downloads 0
HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECTS OF THE AQUEOUS EXTRACT OF TURMERIC (CURCUMA LONGA) IN RIFAMPICIN AND ISONIAZID-INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATS
Objectives: The present study was designed to estimate the influences of oral administration of aqueous extract of turmeric (Curcuma longa) in hepatotoxicity and nephrotoxicity induced in rats by isoniazid and rifampicin...
METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF AMPRENAVIR IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY–ELECTROSPRAY IONIZATION–TANDEM MASS SPECTROMETRY
Objective: The main aim of the present study was to develop a sensitive liquid chromatography–electrospray ionization–tandem mass spectrometric technique for the quantitation of amprenavir in human plasma. Methods: Chro...
DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF OROMUCOSAL WAFER OF TRAMADOL HYDROCHLORIDE
Objective: The objective of the present work was the preparation of fast-dissolving film of tramadol HCl (TMH) using water-soluble polymer, to achieve faster onset of action, to improve patient compliance, ease of dosing...
MICROENCAPSULATED LEMONGRASS OIL FOR MOSQUITO REPELLENT FINISHING OF KNITTED COTTON WEAR
Objective: This study was conducted to design the textile structure with mosquito repellent behavior using microencapsulated lemongrass extract.Methods: Lemongrass oil extracted from Cymbopogon citratus by a hydro distil...
ATOMIC ABSORPTION SPECTROPHOTOMETER – A VERSATILE TOOL FOR THE ESTIMATION OF NICKEL CONTENT IN DRONEDARONE
Objective: The present investigation is to develop a validated analytical method for the determination of nickel content in dronedarone hydrochloride bulk drug by atomic absorption spectrophotometer (AAS). Methods: Samp...