The Value of DNS1 Antigen for Early Detection of Dengue Infection in Children: The Changing Sensitivity
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 7
Abstract
Introduction: The recent epidemics of dengue in India have highlighted that presentation of Dengue is confusing and higher percentage of severe forms of dengue are affecting children. Aim and Objectives: To re-evaluate the role of DNS1 Antigen in the detection of dengue infection early in the symptomatic stage and assess the severity earlier. Materials and Methods: It is a retrospective study done in a tertiary care hospital by analyzing dengue positive 150 children from a total 312 children admitted here for suspected dengue fever. They were clinically categorized according WHO criteria. The findings were tabulated and correlations and significance of various parameters were looked for with latest version of SPSS. Results: More number of male children had dengue. Most of the DNS1 positive cases were seen within 3 days. Mild forms were more than severe variety and more of the younger groups had mild infection. Many older children had NS1 titer values >11, which is statistically significant. Conclusion: Our study affirms that DNS1 Ag is still very useful to detect the dengue infection early but could not recognize the severity
Authors and Affiliations
Dr Prof. N. K. Rajendran
Keywords
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