THERAPEUTIC EFFECT OF TAMARINDUS INDICA EXTRACTS ON THE PATHOGENESIS OF ENTAMOEBA HISTOLYTICA IN-VIVO
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 7
Abstract
Entamoeba histolytic is a protozoan parasite which causes amoebiasis, about 50 million people are affected yearly, and it caused more than 100,000 deaths per year. The study investigates the therapeutic effect of ethanolic and aqueous Tamarindus indica leaves extracts on infected rats with Entamoeba histolytica. Twenty-one Rattus norvegicus rats were infected with Entamoeba histolytica and divided into seven groups (three rats in each group). Groups (1, 2, and 3) were treated with aqueous Tamarindus indica extracts at doses 125, 250, and 500 mg/kg respectively for ten days. Groups (4, 5 and 6) were treated with ethanolic extract of Tamarindus indica at doses 125, 250, and 500 mg/kg respectively for ten days. Group (7) was left untreated as a positive control group. The results showed a significant decrease at p≤0.05 in the numbers of parasite cell from the second day of treatment in all the groups treated with aqueous as well as ethanolic extract. This decrease gradually continued during the days of treatment until it reached zero on the last day of treatment for the dose of 500 mg/kg for both aqueous and ethanol extract. Histopathological study showed that Entamoeba histolytica causes mucosal damage, inflammation and necrosis for colon, while ethanolic extract of Tamarindus indica at dose 500 mg/kg repairs the parasite damage in comparison with a range of positive and negative control groups. Extracts of Tamarindus indica leaves indicated neither any toxic effect nor mortality up to the 1000 mg/kg.
Authors and Affiliations
Mansour Abdulnabi H. Mehdi et al.
Keywords
Related Articles
- EP ID EP607045
- DOI 10.13040/IJPSR.0975-8232.10(7).3250-56
- Views 99
- Downloads 0
STABILITY INDICATING GREEN ANALYTICAL GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN PURE AND MARKETED FORMULATIONS
The current work defines development of a simple, rapid and precise method based on gas chromatography coupled with Flame Ionization Detector (GC-FID) for the quantitative estimation of diphenhydramine (DPH) present in t...
THE APPLICATION OF ULTRASOUND IRRADIATION AS AN ALTERNATIVE METHOD FOR THE PREPARATION OF 99mTc-OCTREOTIDE RADIO COMPLEX
This approach was launched to evaluate the application of ultrasound waves for the preparation of 99mTc-Octreotide radio conjugate sample. The 740MBq (20 mCi) of 99mTc-Octreotide samples were prepared by the boiling wate...
THE HEPATIC CYP3A4 UPREGULATED INCREASED METABOLISM IN RESPONSE TO PHYSICAL ACTIVITY AT HIGH ALTITUDE
The present study was designed to assess the pharmacokinetics of drug metabolized by hepatic cytochrome 3A4 (CYP3A4) in human volunteers with physical activity at the high altitude hypobaric hypoxic environment. The Inte...
ASSESSING THE EFFECT OF FARTLEK TRAINING ON PERCEIVED WELLNESS OF UNIVERSITY STUDENTS OF SAUDI ARABIA: A RANDOMIZED CONTROLLED TRIAL
Wellness is described as positive health of an individual as indicated by the quality of life and a sense of well-being. This research aimed to assess the effect of supervised fartlek training on Perceived Wellness of Un...
THE UNDERSTANDING AND ADHERENCE OF HIV-INFECTED PREGNANT WOMEN TO THERAPY IN A SOUTH-EASTERN STATE OF NIGERIA: A CROSS-SECTIONAL ASSESSMENT
Introduction: Appropriate understanding and adherence to antiretroviral regimens are important requisites to the presentation of good outcomes in the Prevention of Mother-to-Child Transmission (PMTCT) of HIV/AIDS. Object...