Thrombosis in Iron Deficiency and Iron Deficiency Anemia: A Review of our Cases and the Relevant Literature
Journal Title: Open Access Journal of Oncology and Medicine - Year 2018, Vol 2, Issue 3
Abstract
We evaluated our thrombosis cases for iron deficiency (ID) or iron deficiency anemia (IDA) retrospectively and reviewed the literature. We established that iron parameters were studied in 17 of 64 patients with thrombosis and 2 of 17 patients had IDA. Case 1 (age 16, female) had occlusions in sigmoid and transverse sinuses and right jugular vein and case 2 (age 15, male) had infarct in right cerebellar hemisphere. While case 1 additionally had mastoiditis, high Factor (F) VIII and PAI 4G/5G polymorphism, case 2 who underwent a recent aortic graft insertion operation for aortic aneurysm had high serum lipids, lipoprotein a, homocysteine, FVIII, d-dimer. Of 54 thrombosis cases with ID/IDA in the literature, cerebral thrombosis made up of 70.4% of all the cases, venous cerebral occlusions comprising 100% and 66% of venous thrombosis in children and adults respectively. Our findings show that ID/ IDA may be a risk factor for thrombosis, especially in cerebral veins. Many cases of thrombosis have been reported in both children and adults, associated with iron deficiency (ID) or ID anemia (IDA) so far [1-40]. Additionally, the frequency of severe anemia [1] or IDA [2] in adults with cerebral [1] or deep venous thrombosis with/without pulmonary embolism [2] were shown significantly higher than that of the healthy controls. We previously showed by thromboelastogram that children with IDA had a tendency to thrombosis [41]. Herein, we evaluated our patients with IDA and thromboembolism followed in our clinic and reviewed the relevant literature (Tables 1-3). We examined the charts of our patients treated for thrombosis during 2013-2016 and had concomitant IDA/ID; additionally we studied the literature between 1972-2016, through ‘EntrezPubMed and Turkish Citation Index’ databases, matching the key words ‘thrombosis, thromboembolism, hypercoagulability; abnormal coagulation’ with ‘ID or IDA.
Authors and Affiliations
Ceren Kılcı, Lale Olcay, Taner Sezer, I Zafer Ecevit, Birgül Varan, Murat Özkan
Keywords
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- EP ID EP589144
- DOI 10.32474/OAJOM.2018.02.000139
- Views 106
- Downloads 0
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