To Evaluate The Role Of Platelet Rich Plasma As Artificial Hematoma In Bone Healing In Cases Operated With Open Reduction Technique
Journal Title: International Journal of Orthopaedics Traumatology & Surgical Sciences - Year 2018, Vol 4, Issue 1
Abstract
Aim: Platelets are the natural storage vessel for various growth factors and cytokines that promote blood coagulation, tissue repair, and bone healing. Platelets are the one present in the fracture hematoma which are responsible for starting the schematic orchestrated fracture healing cascade. But in cases where we open the fracture site due to various reasons we take away this precious advantage. In this study we want to study the effect of platelet rich plasma (PRP) as artificial hematoma in case where we need to open the fracture site. Method: This randomised study was carried out in 42 patients of post traumatic acute fracture shaft of femur. These patients were divided into two groups: study group A (n= 19) which were operated with open intramedullary nailing with PRP application and control group B (n= 23) which were operated with open intramedullary nailing. Results were compared clinically by Calori’s criteria and radiologically by radiological assessment of fracture healing by measuring the cortex to callus ratio on monthly follow up visits, till 6 months. Results: On measuring and comparing the cortex to callus ratio of group A and B every month, we found a statistically significant difference in the volume of callus at 3rd month of follow up. At other months, though the group A had a better cortex to callus ratio than group B, this difference was not statistically significant. Conclusion: PRP has shown to increase the volume of callus formation at fracture site in case of acute fractures operated with open reduction methods and this difference was statistically significant at 3 months follow up. So PRP does have an osteogenic potential in bone healing and promote callus formation in acute fracture operated with open reduction technique.
Authors and Affiliations
Jeetesh Gawande, Sanjay Upadhyay
Keywords
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