Trace Element Status in Type 2 Diabetes: A Meta-Analysis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 5
Abstract
ABSTRACT Introduction: Type 2 diabetes is a chronic metabolic disorder that has been associated with alterations in the status of trace elements, including zinc, copper, iron and manganese. However, clinical studies reporting statuses of these trace elements in type 2 diabetes patients compared to controls have shown conflicting results. Aim: This meta-analysis aimed to summarize the existing literature on the statuses of zinc, copper, iron, and manganese in type 2 diabetes mellitus patients. Materials and Methods: A literature search of Embase, PubMed, EBSCOHost, ScienceDirect, Scopus, Cochrane library and Web of Science electronic databases was conducted to find studies published from 1970 to November 2016 that compared the trace elements of interest between type 2 diabetic patients and healthy controls. The bias corrected Hedges’ g, was utilized as the effect sizes. Due to the biological interaction between trace elements, it is important to collectively evaluate the statuses of these minerals in type 2 diabetes. Thus, the robust variance estimation method was chosen to handle dependency between multiple outcomes. Results: A total of 52 studies met the inclusion criteria, amounting to 98 effect sizes. Diabetic patients (n=20183) had significantly lower zinc status when compared to controls (effect size = -1.73, p<0.01); whereas copper (effect size = 1.10, p<0.05) and ferritin levels (effect size = 1.05, p<0.01) were significantly higher. Although not significant, ceruloplasmin (effect size = 1.85, p=0.06) and iron (effect size = 1.42, p=0.06) levels were higher, and manganese (effect size = 0.27, p=0.34) was lower in patients. Conclusion: Results from this meta-analysis indicate lower zinc status accompanied by increased copper and ferritin levels in patients with type 2 diabetes when compared to controls.
Authors and Affiliations
Namrata Sanjeevi, Jeann e Freeland-Graves, Natasha S. Beretvas, Prageet K. Sachdev
Keywords
Related Articles
- EP ID EP523089
- DOI 10.7860/JCDR/2018/35026.11541
- Views 65
- Downloads 0
Weight Loss and/or Hypernatraemia in Inadequately Breastfed Term Neonates having Non-haemolytic Unconjugated Hyperbilirubinaemia
ABSTRACT Introduction: Insufficient breast milk intake can lead to increased incidence of neonatal jaundice, inadequate weight gain, hypernatraemic dehydration in neonates and occasionally may cause serious complications...
Effect of Rocker Soled Shoe Design on Walking Economy in Females with Pes Planus
Introduction: The energy cost is increased during walking in pes planus condition whereas, energy cost during walking using rocker bottom shoes is debatable. Aim: To determine the walking economy with rocker soled shoes,...
Soft Tissue Foreign Body: Utility of High Resolution Ultrasonography
Introduction: Minor percentage of wooden foreign bodies is radio-opaque. High Resolution Ultrasonography (HRUSG) though existing is sparsely used as a primary imaging modality for diagnosis and localization of retained f...
Scrub Typhus Complicated by Acute Respiratory Distress Syndrome and Haemophagocytic Lymphohistiocytosis in a Young Patient
ABSTRACT Scrub typhus is an endemic rickettsial disease causing vasculitis involving the small vessels of the body. Haemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterised by excessive unb...
Pericardial Haemangioma: A Common Tumour in an Unusual Location: Case Report and Review of Literature
Overall incidence of primary cardiac tumour ranges from 0.0017% and 0.27% at autopsy. Cardiac haemangiomas are rare, and account for 2.8% of benign cardiac tumours. Pericardial haemangiomas, in particular are extremely r...