Traditional Chinese Medicine in Colorectal Cancer Therapy: A Focus on Panax quinquefolium L. through Text Mining and Network Medicine Approaches
Journal Title: Journal of Experimental and Clinical Application of Chinese Medicine - Year 2024, Vol 5, Issue 2
Abstract
Background: This study aimed to identify traditional Chinese medicines (TCMs) with potential anti-colorectal cancer (CRC) properties and their core active constituents. Methods: A comprehensive review of the literature regarding CRC treatment using TCM was conducted using the PubMed database. A text mining approach was employed to ascertain the correlation between TCM and CRC, highlighting the top ten TCMs. The most significantly correlated TCM underwent network medical analysis. Component data were sourced from the TCMSP and HERB databases, while their targets were identified through public databases. Concurrently, various databases were utilized to pinpoint CRC-associated target genes. Network medicine was then employed to ascertain the network proximity between component targets and CRC genes. Potential targets for both TCMs and CRC were mapped and were subsequently input into the String database to craft a protein-protein interaction (PPI) diagram. Visualization and analysis of the TCM-ingredients-targets and PPI diagrams were performed using Gephi 0.9.2. Lastly, DAVID database was used for GO and KEGG pathway enrichment analyses of the intersecting targets. Results: Text mining revealed Panax quinquefolium L. displays the most pronounced anti-CRC properties. Notably, key ingredients of Panax quinquefolium L., including Ginsenoside Rb3, Papaverine, Ginsenoside Rg3, and Ginsenoside Rb1, were found to have substantial impacts on cancer and microRNA-cancer signaling pathways. Conclusions: The TCM Panax quinquefolium L. showcases a strong potential in CRC treatment, particularly due to the efficacy of Ginsenoside Rb3 and Ginsenoside Rg3. This study provides a foundational analysis for further exploration into the therapeutic effects and underlying mechanisms of Panax quinquefolium L. in combating CRC.
Authors and Affiliations
Airong Ren, Mengchen Liu, Mei Huang, Shixun Zhang, Yanli Fu, Wei Shi
Keywords
Related Articles
- EP ID EP746605
- DOI https://doi.org/10.62767/jecacm502.1121
- Views 85
- Downloads 0
The Effects of Multiple Kidney-Tonifying Chinese Medicines on Thymus Regeneration in Rapamycin-Induced Mice
Background: Rapamycin is universally recognized as a potential anti-aging drug, the important functional activities of which involve induction of reversible acute atrophy of the thymus and normal regeneration after disco...
Exploring the Mechanism of Astragalus membranaceus in the Treatment of Post-Infectious Irritable Bowel Syndrome Based on Random Walk with Restart Algorithm and Experimental Validation
Background: This study aims to screen target genes with high relevance by running the random walk with restart (RWR) algorithm on the target background network, and to explore the mechanism of Astragalus membranaceus (AM...
Efficacy of Azithromycin Injection Combined with Levofloxacin Capsule and Ambroxol Injection in the Treatment of Mycoplasma Pneumonia
Objective: To investigate the clinical efficacy and safety of combining azithromycin injection with levofloxacin capsule and ambroxol injection for the treatment of Mycoplasma pneumonia. Methods: A total of 160 cases of...
Research Progress on Pharmacological and Toxicological Effects of Bavachin
Objective: To analyze and summarize the latest research progress regarding pharmacological and toxicological effects of bavachin. Methods: Through retrieval of all bavachin-related reports on pubmed, CNKI, Wanfang databa...
Application of Tongbian Scraping Combined with Suhuang Zhike Capsule in Chronic Obstructive Pulmonary Disease
Objective: This study investigates the application of Tongbian scraping combined with Suhuang Zhike capsule in chronic obstructive pulmonary disease (COPD). Methods: 43 patients with COPD treated with Tongbian scraping c...