TRANSFEROSOME: AN OPPORTUNISTIC CARRIER FOR TRANSDERMAL DRUG DELIVERY SYSTEM 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3

Abstract

Transdermal route of drug delivery system has received a great attention in pharmaceutical research and it has already proved its superiority in various respects than oral route, which has a number of problems in drug delivery system. However, the permeation of hydrophilic ioniazable species of drug always has been denied by the intrinsic barrier or stratum corneum for providing local or systemic actions. Transferosomes are ultra deformable vesicles, elastic in nature, which can squeeze itself through a pore and it is more advantageous than the conventional liposome due to its high elasticity, which offers its penetration through narrow constriction without measurable loss. The high permeability of transferosome across the skin also depends on its deformability and intermediate attachment sites for membrane fusion due presence of ripples in vesicles surface. Its infrastructure posses both hydrophilic and hydrophobic moieties together and it can entrap both type of drug. They can act as a carrier for low as well as high molecular weight drugs e.g., analgesics, anesthetics, corticosteroids, sex hormones, anticancer drugs, insulin, gap junction proteins, albumin, etc. 

Authors and Affiliations

Malakar Jadupati, Amites Gangopadhyay , Amit Nayak

Keywords

Related Articles

ANTIOXIDANT PROFILING OF SELENIUM FORTIFIED TOMATO (Solanum lycopersicum) 

In recent years the consumption of processed vegetables has been escalating. Similarly, food quality and its effects on human health have become crucial issues. Since selenium (Se) is an important microelement due to its...

BENZIMIDAZOLES: THE LATEST INFORMATION ON BIOLOGICAL ACTIVITIES 

Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and a privileged structure in medicinal chemistry. Benzimidazole and its derivatives play an important role in medical field wit...

VALIDATION OF HPTLC METHOD FOR QUANTITATIVE ESTIMATION OF L-DOPA FROM MUCUNA PRURIENS 

In the present study, high performance thin-layer chromatographic method was developed and validated for the quantification of L-Dopa from Mucuna pruriens (Black-coloured seeds). TLC aluminium plates precoated with silic...

RETROSPECTIVE ANALYSIS: TO ENHANCE PATIENT SAFETY BY MINIMIZING MEDICATION ERRORS IN TERTIARY CARE CARDIAC HOSPITAL 

To identify and measure the frequency of medication errors, to understand the causes for errors and best strategies to decrease medication errors rate in a cardiac hospital New Delhi. The Retrospective study of 137 case...

PHYTOCHEMICAL INVESTIGATION OF THE ROOTS OF CALOTROPIS PROCERA (AIT.) R. BR. 

Two new phytoconstituents characterized as n-tetradecanyl n-hexadec-9-enoate (n-tetradecanyl palmitoleate) (4) and 18µH – urs– 12 – en - 3β, 25 - olide (proceraursenolide) (5) have been isolated for the first time from t...

Download PDF file
  • EP ID EP114175
  • DOI -
  • Views 64
  • Downloads 0

How To Cite

Malakar Jadupati, Amites Gangopadhyay, Amit Nayak (2012). TRANSFEROSOME: AN OPPORTUNISTIC CARRIER FOR TRANSDERMAL DRUG DELIVERY SYSTEM . International Research Journal of Pharmacy (IRJP), 3(3), 35-38. https://europub.co.uk/articles/-A-114175