Transforming growth factor β1 as an indicator of the progression of chronic viral hepatitis
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 1
Abstract
Transforming growth factor b1 (TGF b1) is main cytokine responsible for progression of fibrosis in chronic liver disease. Factors having impact on progression in chronic viral hepatitis (cvh) are not clearly identified.The aim of the study was to evaluate factors having influence on progression of fibrosis in cvh.Hepatic concentration of TGF b1 (Quantikine Immunoassay Kit) was measured in 78 patients: 52 with cvh C, 19 with cvh B, 7 with non alcoholic fatty liver disease and autoimmune hepatitis. The results were analyzed in relation to grade of inflammation and necrotic changes as well as stage of fibrosis in histological analysis of liver bioptates (according to Batt and Ludwig’s scale), insulin resistance (HOMA-IR>2.259), serum alanine aminotransferase (ALT), asparagine aminotransferase (AST) and g-glutamyltranspeptydase (g-GTP) activity, HCV and HBV viral load, sustained viral response to interferon a therapy in cvh C (SVR), body mass index (BMI), adipose tissue amount and presence of metabolic syndrome (EGIR 1999).There was correlation between TGF b1 and inflammatory-necrotic process activity on the basis of histological examination (p<0.00001), ALT activity (p=0.0177), degree of fibrosis (p=0.0002). TGF b1 concentration was statistically significantly higher in patients with liver steatosis (p=0.0144), elevated g-GTP activity (p=0.0296), and insulin resistance (p=0.057).No statistically significant difference was found in TGF b1 concentration in relation to the rest of analyzed factors.The results confirmed close correlation between TGF b1 and progression of liver injury as well as correlation between progression of cvh and liver steatosis, insulin resistance and oxydative stress resulting in increase of serum g-GTP activity.
Authors and Affiliations
Andrzej Cieśla, Tomasz Mach, Krystyna Pierzchała-Koziec, Joanna Zubel, Paweł Skwara
Keywords
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