TRANSLATIONAL ASPECTS OF PLACE OF HYDROGEN SULFIDE-RELEASING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON THE TOMORROW’S LANDSCAPE FOR STRESSASSOCIATED DISORDERS
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2017, Vol 49, Issue
Abstract
Non-steroidal anti-infl ammatory drugs (NSAID) are ones of the most widely prescribed drugs in medicine and up-to-date data have expanded their therapeutic role into complex biological processes such as oncogenesis, tissue repair, and different disorders related to aging, despite of dangerous adverse effects which can be fatal (gastrointestinal (GI) bleeding etc). Latest extensive research of multifunctional activities of hydrogen sulfi de (H2S) has proven its potent cytoprotective and vasoprotective, as well as anti-infl ammatory effects and developed background of introduction novel NSAID-H2S-releasing moiety compounds (NSAID-H2S). Different NSAID-H2S were created and tested in multicentral investigations (Wallace, 2007-2017) recently.
Authors and Affiliations
N. Bula, Ya. Pavlovsky, V. Student, O. Revenko, J. L. Wallace, Oksana Zayachkivska
Keywords
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