Translational Pharmacology: New approach of drug discovery
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 2
Abstract
Increasingly, the field is recognizing the need to enable a closer collaboration of industry and academia to create a more efficient system for developing new drugs. In parallel with this, the world of drug discovery has seen the emergence of translational research as an alternative approach to the creation of new drugs, and there is growing support for the claim that this strategy may provide solutions to some of the woes of the pharmaceutical industry. Translational medicine and translational pharmacology have become terms increasingly used to describe the focus of applied pharmacological research to ultimately help patients. Yet, the number of effective medicines reaching the approval stage continues to decline. Drug discovery represents the first step in the creation of new drugs, and takes place in academic institutions, biotech companies, and large pharmaceutical corporations. With the rise of translational research these relationships are shifting and new hubs are emerging, as key players seek to pool the expertise necessary to generate new therapies by linking laboratory discoveries directly to unmet clinical needs.
Authors and Affiliations
Deepak K Bharati
Nephroprotective activity of heliotropium indicum in rifampicin induced nephrotoxicity rats
The nephroprotective effect of whole plant of ethanolic extract of Heliotropium indicum was confirmed by our study. In Rifampicin treated group urea, uric acid and creatinine levels are increased in serum and urine where...
Aerobic Exercises: To trim down menstrual distress among adolescent girls
Menstrual distress is a hindrance that curtails the quality of life, especially among the adolescent period where the effects are at its peak which resolves as they ovulate progressively. The purpose is to reduce the me...
Potential use of Quercus infectoria gall extracts against urinary tract pathogenic bacteria
Galls of Quercus infectoria have been traditionally used by Malaysian women as a remedy after childbirth and also to prevent various infections including urinary tract infection (UTI). This study aimed to evaluate the i...
Polyherbal Formulation Development for Anti-asthmatic activity
The aim of the present work is to develop and standardize the herbal formulations for asthma using well documented herbs. Three herbs selected for this work namely Tylophora indica, Tephrosia purpurea and Vitex negundo...
Evaluation of anti-hemolytic activity of green tea aqueous extracts by in vitro method
Hemolysis is a disorder of destruction of RBC cells in our body; chloroquine is the drug that regularly preferred to anti-malarial activity. This current study observes the destruction of RBC cells by chloroquine when t...