TRANSMISSION BLOCKING STRATEGY FOR MALARIA ERADICATION: THE ROLE OF ANTIMALARIAL AGENTS
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 10
Abstract
Elimination and Eradication is an important component of the Global Strategy for combating malaria, and one of the ways of achieving this purpose is blocking the transmission of malaria parasites from humans to mosquito vectors. The ability of Plasmodium to cease asexual replication in the erythrocytes of the human host and commit to the formation of gametes necessary for sexual replication in the gut of the mosquito vector is essential for efficient transmission of malaria. Although a conserved member of the Apicomplexan AP2 family of transcriptional factors acts as the master switch in triggering the transcriptional cascade that initiates gametocytogenesis, some environmental factors including some antimalarial drug treatments, are believed to switch on the gene(s) that determine the commitment to the sexual phase. Antimalarial agents have different effects on gametocyte carriage depending on their mechanisms of action. This review enumerates the role of various classes of antimalarial agents in either promoting or preventing plasmodium gametocytogenesis and points out the need to, in addition to exiting gametocytocidal, design new drugs that are capable of preventing gametocytogenesis and killing mature gametocytes in humans; or preventing gametogenesis and fertilization in the mosquito.
Authors and Affiliations
T. O. Johnson
Keywords
Related Articles
- EP ID EP556781
- DOI -
- Views 66
- Downloads 0
SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES
2-Amino-1-aryl-1, 4, 5, 6, 7, 8-hexahydro-4-phenyl-quinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidine-malononitrile (2) and the appropriate of aniline derivative...
MEDICINAL PLANTS SUPPORT THE AMYLIN-SUPPRESSED VIABILITY OF ISLET β-CELLS
The proliferation of β-cells is the main contributor to the mass cell maintenance in the pancreatic islets. In our earlier work the suppression of β-cell growth by aggregated peptide hormone of the pancreas, amylin, has...
CYTOTOXIC EFFECT OF ALPINIA NIGRA CRUDE EXTRACTS OBTAINED FROM ITS RHIZOMES
The present study was aimed to investigate the cytotoxic activity of different fractions (petroleum ether, ethyl acetate & chloroform) of the rhizome of Alpinia nigra – a plant belonging to the family Zingiberaceae. The...
WOUND HEALING AND IN-VIVO ANTIOXIDANT ACTIVITY OF MIMUSOPS ELENGI LINN. LEAF EXTRACT
Objective: Phytochemical and pharmacological investigation on the leaves of Mimusops elengi Linn. for Wound healing and In-vivo Antioxidant Activity in albino mice. Material and Methods: The methanolic extract of leaves...
APPLICATION OF MOLECULAR BEACON BASED BIOSENSOR AGAINST rs699 SNP IN HYPERTENSIVE AND NON- HYPERTENSIVE PUNJABI POPULATION
Molecular beacons have shown their topnotch potential in a variety of basic research, biomedical detection and in clinical diagnosis. Their excellent selectivity, sensitivity, detection without separation have made them...