CYTOTOXIC EFFECT OF ALPINIA NIGRA CRUDE EXTRACTS OBTAINED FROM ITS RHIZOMES
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 1
Abstract
The present study was aimed to investigate the cytotoxic activity of different fractions (petroleum ether, ethyl acetate & chloroform) of the rhizome of Alpinia nigra – a plant belonging to the family Zingiberaceae. The rhizome of Alpinia nigra was extracted with organic solvent, and the extracts were fractionated by using three fractions (petroleum ether, ethyl acetate & chloroform). The petroleum ether, ethyl acetate & chloroform soluble fractions of Alpinia nigra were screened for cytotoxic activity using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it can be well predicted that petroleum ether, ethyl acetate and chloroform-soluble fractions of Alpinia nigra rhizome possess cytotoxic principles (with LC50 1.245 mg/ml and LC50 2.151 mg/ml and LC50 2.737 mg/ml respectively) comparison with positive control vincristine sulphate (with LC50 0.563 mg/ml). All the extracts of Alpinia nigra showed moderate cytotoxic activities in this experiment. The results of this study are highly promising.
Authors and Affiliations
Binita Paul et al.
Keywords
Related Articles
- EP ID EP554745
- DOI -
- Views 52
- Downloads 0
THROMBOLYTIC AND MEMBRANE STABILIZING ACTIVITIES OF LAUNAEA SARMENTOSA
This study was carried out to evaluate the thrombolytic and membrane stabilizing activities of Launaea sarmentosa plants. The crude methanolic extract of L. sarmentosa (whole plants) was investigated for in vitro thro...
SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME SUBSTITUTED PYRAZOLE DERIVATIVES
A series of substituted acetophenones are condensed with hydrazides to the corresponding hydrazones which are subsequently cyclized by using vilsmier-Haack reaction to give new pyrazole derivatives. All the compounds 4a,...
SYZYGIUM CUMINI: A REVIEW
Eugenia jambolana Lam., commonly known as black plum or “jamun” is an important medicinal plant in various traditional systems of medicine. It is effective in the treatment of diabetes mellitus, inflammation, ulcers and...
A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF MICHELIA CHAMPACA LINN. FAMILY: MAGNOLIACEAE
Michelia Champaca Linn., belonging to family Magnoliaceae, is commonly known as Champa. It is a medium size evergreen tree highly distributed in eastern Sub-Himalayan tract, West Bengal, Myanmar, and South India in addit...
IN VITRO AND IN VIVO TOXICOLOGICAL EVALUATION OF AQUEOUS EXTRACTS FROM BENINESE PLANTS: SENNA SIAMEA LEAVES AND SARCOPCEPHALUS LATIFOLUS STEM ROOTS
The toxicity of aqueous extracts of S. siamea leaves, S. latifolius roots collected in Benin and their mixture (1/1, w/w), was evaluated on female non pregnant rats, albino wistar genus. They were treated during two week...