Trends for Antioxidant Power of Phytochemicals from Pergularia tomentosa L. (Asclepiadacea) Whole Plant
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 2
Abstract
Traditional ethnomedicinal use of plant is recognized as an important potential source for compounds used in mainstream medicine. Herein, the in-vitro antioxidant property and phytochemical composition of Pergularia tomentosa L. plants widely used was evaluated. 1, 1-diphenyl-2-2-picrylhydryzyl (DPPH) radical scavenging effect of the crude extract and its fractions were determined between 0.1, 0.25, 0.5, 1.0 2.5, and 5.0mg/ml spectrophotometrically. While, qualitative phytochemical test revealed the presence of phenolics, flavonoids alkaloids, saponins, steroids and glycoside. A systemic activity trends analysis indicated that P. tomentosa L. whole plant has relative antioxidant activity ranged from crudes extract to basic, acidic, methanolic and hexane fractions in the order of increasing sequence (CRD>BSC>ACD>MET>HEX). The crude extract haven highest antioxidant activity, followed by the basic fraction (alkaloid) respectively compared to acidic and methanolic fraction. Hexane has the lowest activity. This studied medicinal plant have interesting antioxidant properties and a phytochemical composition that could provide scientific evidence for some folk uses in the treatment of diseases related to the production of ROS and oxidative stress. Thus, trends for activity flow of antioxidant properties demonstrated in this work will provide evidence for researcher to isolate active antioxidant compound from the fraction with highest activity (basic fraction i.e. alkaloid). Keywords: Pergularia tomentosa L. Asclepiadacea, Antioxidant activity, and phytochemical screening.
Authors and Affiliations
Rufai Yakubu, Fatima Musa Jibril, Aminu Lukman, Fatima Sheikh
Keywords
Related Articles
- EP ID EP376933
- DOI -
- Views 86
- Downloads 0
Anatomical and Phytochemical Evaluation of Sansevieria roxburghiana Schult. & Schult. F. (Rhizome).
In the present study, rhizome of Sansevieria roxburghiana Schult. & Schult. f. (Agavaceae),was evaluated for the preliminary phytochemicals and anatomical characteristics. Petroleum ether, chloroform, methanol and wa...
Influence of anticoagulant therapy in assessment of Fibrinolysis activity in post acute myocardial infarction patients
Acute myocardial infarction is a serious disease in which a patient can survive or die depending on his or her attitude towards life, myocardial infarction, commonly known as a heart attack, is the irreversible necrosis...
Novel Topical Nanoformulations: An Overview
Abstract: Novel drug delivery system (NDDS) refers to the approaches, formulation, technologies and systems for transporting a pharmaceutical compound in the body as needed to safety achieve its desired therapeutically e...
Comparing the therapeutic action of octreotide, trimetazidine and their combination by pro-inflammatory and enzymatic changes in L-Arginine induced acute pancreatitis in male rats
Acute pancreatitis continues to be associated with significant rates of mortality and morbidity, and therapeutic options are still very limited. Various theories have been suggested regarding the pathophysiology of acute...
Role of Antidiabetic Drug Metformin in Ovarian Cancer Cells in Vitro
Abstract:Ovarian cancer is one of the most common lethal gynecological malignancies. Despite an initial 70-80% response rate, most patients relapse within 1-2 years and develop chemo resistance. Tumor cells have the capa...