TRIOXACARCINS AS A PROMISING CLASS OF ANTICANCER DRUGS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 10
Abstract
Trioxacarcins are intricate and polyoxygenated natural products with exceptional anti-malarial and antineoplastic flair. Trioxacarcins are extracted disclosing six of their types, namely, trioxacarcin A, B, C, D, E and F. Much valuable work has been executed in the line of synthesis of trioxacarcins and their derivatives keeping brevity of steps and efficiency of reactions in focus. Additional efforts are still requisite in formulation and biological studies of trioxacarcin D, E and F as literature proves efforts made on exploration of A, B and C types mainly. This class has an outstanding feature of covalently binding with DNA duplex, therefore, underlining its prospectives to manipulate genes for impeding serious diseases. Nature encloses remedy for every affliction and trioxacarcins class of drugs is a medicinal treasure for modern world facing agitating health complications like cancer.
Authors and Affiliations
Syeda Khair-ul-Bariyah
Keywords
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