Tuberous Sclerosis Complex and Autism
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 4
Abstract
Introduction: Tuberous sclerosis is a common autosomal dominant neurocutaneous disorder characterized by abnormal tissue growth resulting in benign tumors, hamartomas, and non growing lesions, hamartias, in numerous organs including skin, brain, eye, heart and kidney. Tuberous sclerosis complex (TSC) is frequently associated with autistic behavior. Objective: The aim of this study was to determine the frequency of autism in patients with TSC and the relationship between autism and infantile spasms (IS) and mental retardation. Material and Methods: The participiants in this study were 17 (6 female, 11 male) patients seen in Child Neurology Unit at the Ege University Hospital Department of Neurology. The assessment of autism was made with clinical evaluation, DSM IV and CARS. Results: Autism was seen in 35.3% (6/17) of patients. IS and mental retardation were strongly associated with autism but there wasn’ t statistically significance (p>0.05). Conclusion: Autism is seen frequently in patients with TSC and our results supports this data. There is a high occurence of IS and mental retardation in autism in TSC but they are not inevitably concomittant with it.
Authors and Affiliations
İrem AŞAN, Sabiha TÜRE, Ahmet GÖKÇAY, Hatice KARASOY
Keywords
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