Tumor Budding in Colorectal Carcinomas.
Journal Title: Turkish Journal of Pathology - Year 2012, Vol 28, Issue 1
Abstract
Objective: In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated. Material and Method: Haematoxylin and eosin stained slides of 73 cases with colorectal carcinoma were retrospectively evaluated for the presence and intensity of tumor budding by 2 observers. After the specimens were assessed, the highest density of tumor budding area was counted in a microscopic field of x200. Cases were separated into 2 groups according to tumor budding density as low grade ( < 10) and high grade (≥10). The relationship of these groups with depth of tumor invasion, histological grade, vascular invasion and lymph node involvement was investigated. Results: Of the 73 colorectal carcinoma cases, 33 (45.2%) had low and 40 (54.8%) had high grade tumor budding density, respectively. There was a statistically significant relationship between high grade tumor budding density and histological grade (p=0.042), lymph node involvement (p=0.0001) and vascular invasion (p=0.0034). Conclusion: High grade tumor budding density is associated with aggressive phenotypical features in colorectal carcinoma.
Authors and Affiliations
Sevda Sert Bektaş, Gülsün Inan Mamak, Ibrahim Metin Cırış, Kemal Kürşat Bozkurt, Nilgün Kapucuoğlu
Keywords
Related Articles
- EP ID EP86292
- DOI 10.5146/tjpath.2012.01099
- Views 71
- Downloads 0
Amylase Crystalloids on Fine-Needle Aspiration of the Salivary Gland
Amylase crystalloids is one of the several types of crystalline structures that can be seen in non-neoplastic and neoplastic salivary gland lesions. Here, a 60-year-old woman with an infraauricular mass existing for two...
Akciğerin sarkomatoid karsinomları: Üç olgu sunumu
Sarkomatoid karsinomlar akciğerin malign tümörlerinin %0.3-1.3'ünü oluşturan nadir görülen bir tümör grubudur. Küçük hücreli dışı akciğer karsinomlarının sarkom veya sarkom benzeri bileşen içeren ayrı bir tipidir. Bu yaz...
Jeneralize morfea-liken skleroatrofik birlikteliği
Lokalize fibrozan hastalıklar, genellikle çocukluk çağında başlayan, nadir görülen bir hastalık spektrumudur. Morfea ve liken skleroatrofik, bu hastalık spektrumunda yer alan genellikle dermis, subkütan yağ dokusu ve yum...
EZH2, Endothelin-1, and CD34 as Biomarkers of Aggressive Cervical Squamous Cell Carcinoma: An Immunohistochemical Study
Objective: Cervical cancer has an increasing incidence in developing countries with a predominance of squamous cell carcinoma. In this work, we aimed to analyze the role of EZH2, Endothelin-1, and CD34 as indicators of t...
Enteropati-tipi T-hücreli lenfoma olgularında EBER in situ hibridizasyon yöntemiyle Epstein-Barr virüs ilişkisinin araştırılması
“Enteropati-tipi T-hücreli lenfoma (ETTHL)”, intraepitelyal T-lenfositleri kökenli bir “matür ekstranodal T ve NK hücreli lenfoma” türüdür. Tüm non-Hodgkin lenfomalar içerisindeki oranı %1'in altındadır. Gelişiminde glia...