Uric acid – a renal and non-renal risk factor
Journal Title: Postępy Nauk Medycznych - Year 2013, Vol 26, Issue 7
Abstract
As human beings are deprived of uricase, the final metabolite of purines is uric acid and not allantoin. This metabolite was the subject of scientific interest predominantly in patients with heriditary or acquired forms of gout respectively. In the last years uric acid became an important pathogenetic factor involved not only in accelerating progression of different acute and chronic nehropathies but also as a cardiovascular toxin involved in the pathogenesis of arterial hypertension, vascular injury, heart failure and abnormalities of carbohydrate metabolism. These facts were the reason why inhibition of uric acid synthesis became an important therapeutic target. This interest rose even more when the presence of a metabolic link between uric acid and fructose (which is assumed to be a cardiovascular toxin) was proven.
Authors and Affiliations
Eberhard Ritz
Keywords
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