Urinary cystatin C as a biomarker of renal tubular injury
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
Cystatin C (cysC) is an endogenous cysteine peptidase (proteinase) inhibitor that has been intensively investigated as a biomarker of kidney function for many years. It is freely filtered at the kidney glomerulus because of its small size and lack of cysC binding protein. A very small amount of cysC appears in the urine because of its total reabsorption in the proximal tubule and lack of secretion. Since 1985 cystatin C has been studied mainly in serum/plasma as an alternative biomarker to serum creatinine to estimate GFR. In this review we present the recent discoveries concerning urinary cystatin C determination as a tubular injury biomarker.
Authors and Affiliations
Maria Warwas, Agnieszka Piwowar
Keywords
Related Articles
- EP ID EP66531
- DOI -
- Views 179
- Downloads 0
Renal catabolism of albumin – current views and controversies
Albumin is the main protein of blood plasma, lymph, cerebrospinal fluid and interstitial fluid. The protein assists in many important body functions, including maintenance of proper colloidal osmotic pressure, transport...
The clinical significance of fatty acid binding proteins
Excessive levels of free fatty acids are toxic to cells. The human body has evolved a defense mechanism in the form of small cytoplasmic proteins called fatty acid binding proteins (FABPs) that bind long-chain fatty acid...
The role of gastric mucins in interactions with Helicobacter pylori
Helicobacter pylori is a Gram-negative bacterium which colonizes the stomach of over 50% of the world’s population. The pathogen is responsible for many diseases including gastritis, ulcers and also gastric cancers. It i...
Prozdrowotna rola kwercetyny obecnej w diecie człowieka
Kwercetyna jest fitozwiązkiem z grupy flawonoidów roślinnych wykazującym szeroki zakres właściwości, m.in. antyoksydacyjnych, przeciwzapalnych i immunomodulacyjnych. Bierze udział w regulacji wielu procesów komórkowych,...
Fungi of the genus Malassezia as opportunists of humans and animals
Yeasts from the genus Malassezia are common commensals and pathogens found in humans and animals, and are responsible for tinea cases. Due to their specific cell structure, they may be resistant to environmental stresses...