uRole of gene expert in rapid molecular detection of extrapulmonary tuberculosis in tertiary CATE hospital
Journal Title: International Journal of Medical Research and Review - Year 2018, Vol 6, Issue 5
Abstract
Introduction: Tuberculosis, the most common infectious disease with prevalence of 9.6 million globally. Most prevalent (23%) in India. Extrapulmonary tuberculosis (EPTB) accounts for 20% of total burden of tuberculosis. Rapid detection of Mycobacterium Tuberculosis (MTB) is essential for effective disease management. CBNAAT (Cartridge Based Nucleic Acid Amplification Test) or Gene Xpert MTB/RIF assay - novel diagnostic tool to detect MTB and RIF resistance simultaneously. WHO recommends its utility for non-respiratory samples also. Burden of EPTB and drug resistance vary from place to place. Objective: Study was conducted to gather information about burden of disease in our locality and to assesutility of CBNAAT in detecting MTB and rifampicin resistance in suspected EPTB cases. Methods: Retrospective analysis of 281 samples from suspected cases collected in falcon tubes and processed using CBNAAT. Result: Total of 281 extrapulmonary samples received, 67(23.8%) were positive and 214(76.1%) were negative for MTB. Of 67 positives, RIF resistance detected in 1(1.49%) case. Maximum number of MTB detected in the age group 20-30 years (n=23, 34.3%). Among 165 males and 116 females, MTB detected in 44(26.6%) and 23(19.8%) respectively. Out of 281 patients, 24(8.54%) were HIV positive. Of these 24, only 8(33.3%) found positive for MTB. Among 257 non-HIV patients, MTB detected in 59(22.9%). Among different samples received, maximum number were Pleural fluid n=115(40.9%) and Maximum MTB positives found in FNAC samples n=35(52.2%). Conclusion: CBNAAT is a rapid test to detect MTB and rifampicin resistance simultaneously in EPTB and it reduced the treatment abuse in suspected cases.
Authors and Affiliations
Kala Yadhav M L, Veena M
Keywords
Related Articles
- EP ID EP349329
- DOI 10.17511/ijmrr. 2018.i05.06.
- Views 170
- Downloads 0
Blood stream infections with Candida species: a prospective study in a tertiary care center
Candidemia describes the presence of Candidaspecies in the blood [1,2]. Invasive Candidiasis embodies a variety of diseases including Candidemia, dissemi¬nated Candidiasis, meningitis, and endo-phthalmitis. Most common f...
Outcome analysis of patients presenting with neurological manifestations of Plasmodium Vivax malaria in tertiary care hospital of Mumbai
Objective: Plasmodium vivax (P. vivax) infection has been considered for a long time a benign and self-limited disease. Percentage of complicated cases of vivax malaria is on the increasing trend, cerebral malaria being...
Sexual dimorphism in ratio of second and fourth phalanges and metacarpals: A retrospective study
Introduction: There are many features in humans which exhibit sexual dimorphism. A unique feature showing this gender differentiation is the ratio of lengths of index and ring fingers. Sexual dimorphism in finger lengths...
Comparison and correlation of ophthalmic and systemic manifestations with respect to CD4 counts in HIV infected adults
Purpose: To compare and correlate ophthalmic and systemic manifestations with respect to CD4 counts in HIV infected adults. Materials and Methods: In a prospective clinical study, 182 HIV positive patients were evaluated...
Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India
Introduction: Platelets from patients with type 1 and type 2 diabetes exhibit enhanced platelet aggregation activity early in the disease course that may precede the development of cardiovascular diseases. Both atheroscl...