USE OF COLCHICINE FOR POST PERICARDIECTOMY SYNDROME IN PATIENTS WITH CORONARY ARTERY BYPASS GRAFT AND ITS EFFECTS ON SURGICAL INTERVENTION
Journal Title: Kocatepe Medical Journal - Year 2022, Vol 23, Issue 2
Abstract
OBJECTIVE: Postpericardiotomy syndrome (PPS) continues to be one of the most common causes of morbidity after cardiac surgery despite all developments. We investigated whether colchicine is more effective than expected in reducing and eliminating pericardial effusions and inflammation in a short time and significantly reducing surgical interventions in our patients who have pericardial effusion and resistant pericarditis due to PPS after coronary artery bypass grafting. MATERIAL AND METHODS: Fifty-six patients with PPS all of whom coronary artery bypass grafting between January 2015 and January 2020 were retrospectively included in the study. While colchicine was used in the treatment of 24 of these patients, colchicine was not used in the treatment of the other 32 patients. The results obtained from the data were compared. Demographic characteristics, accompanying risk factors, risk analysis, number of anastomoses performed in coronary bypass grafting, drainage amaount and inflammation values were compared between the groups. Factors that affect morbidity and mortality in patients were investigated and analyzed. The effectiveness of colchicine on both treatment and frequency of invasive procedures was investigated. RESULTS: Patients in the study group and control group were compared. It has been determined that colchicine used in the treatment of the patients in the study group was effective in the resorption of pericardial fluid and in reducing the frequency of surgical intervention that may be necessary to drain the pericardial fluid. CONCLUSIONS: The use of colchicine significantly reduced the amount of pericardial effusion and the frequency of surgical intervention that may be required for this. In our clinic, we use it as the first option in patients with PSS in routine practice. In the treatment of non-regressive pericardial effusions and persistent pericarditis after PPS; we think that colchicine is effective and inexpensive treatment method with rare side effects that should be kept in mind before invasive entries. Colchicine is still used safely and successfully in our clinic for the treatment of patients with PPS.
Authors and Affiliations
Ziya YILDIZ
Keywords
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- EP ID EP702627
- DOI https://doi.org/10.18229/kocatepetip.937302
- Views 92
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