Use of Procalcitonin for Optimizing Antimicrobial Therapy in Long Term ICU Patients

Abstract

Most of the studies are conducted to evaluate the role of procalcitonin in the diagnosis and management of sepsis at the time of admission or in a defined set of patients [Respiratory infection, surgical sepsis, neonatal sepsis, emergency department, burn patients etc]. The aim of the study was to determine the role of serial monitoring of PCT-serum level with the clinical assessment of the patients and guiding the antimicrobial therapy. The study was conducted for two months and all patients admitted to ICU with suspected sepsis, were included in the study. Patient’s demography, SOFA score, APACHE II score and other laboratory parameters were recorded. The blood sample was collected on the day of admission and on alternate days till ten days of admission or discharge from ICU whichever comes earlier. The sera were separated and quantitative estimation of PCT was done by ELISA based technique. In total seven patients were included in the study. The median baseline level of PCT was 135.45 ng/ml higher than the other studies. The baseline level had no correlation with severity of illness. Two of the patients admitted with septic shock succumbed to infection. There was 30% increase in PCT from baseline in these patients. All patients, who improved clinically and transfer out of the ICU and survived showed >10% decrease in PCT. The percent change in PCT started increasing a day before clinical deterioration in one of the patient. Hence percent change in PCT level may be used as a supportive marker while escalating/ de-escalating/ continuing same antimicrobial therapy.

Authors and Affiliations

Shilpee Kumar, Karan Sachdeva, Santhosh Rajan, Monika Matlani

Keywords

Related Articles

Molecular Characterization of Cultivated and Wild Genotypes of Punica granatum L. (Pomegranate) by Using SSR Marker

The genetic diversity among 20 pomegranate genotypes including cultivated varieties and wild germplasm by using simple sequence repeats (SSR) markers. Plant genomic DNA was isolated using the modified CTAB method. A tota...

Effect of Chitosan in Radical Scavenging and Bactericidal Activity Isolated from Agaricus bisporus Mushroom

In the present study, Chitin has been extracted from Agaricus bisporus (Button mushroom). The obtained chitin was converted into the more useful chitosan and the crude chitosan extract was measured for its absorption max...

Efficacy of Aquatic Plants for Removal of Heavy Metals from Wastewater

Wastewater treatment is a problem of grave concern in most developing countries. In the last two decades, there has been a lot of research to develop appropriate technologies to alleviate pollution in water resources. Ef...

Homeopathic Remedies, Carcinosin200C and Natrum Sulphuricum200C, Used Intermittently Demonstrate Greater Ameliorative Response in Mice Intoxicated with Liver Carcinogens

Background- In homeopathy, Carcinosin 200C (Car200) and Natrum Sulphuricum 200C (Nat Sulph200), are generally used individually in liver ailments depending on the totality of symptoms. This study was designed to examine...

Association Between Socio-Behavioral Factors and Oral Health Status of 12-15 Year Old School children in Belagavi City- A Cross Sectional Study

Background- Oral health is a multi-factorial concept, determined by knowledge, behavior, and attitude of a person. Like any behavior carried out daily like a habit, oral health behaviors are also repeated like a habit. T...

Download PDF file
  • EP ID EP670898
  • DOI 10.21276/ijlssr.2018.4.3.5
  • Views 95
  • Downloads 0

How To Cite

Shilpee Kumar, Karan Sachdeva, Santhosh Rajan, Monika Matlani (2018). Use of Procalcitonin for Optimizing Antimicrobial Therapy in Long Term ICU Patients. SSR Institute of International Journal of Life Sciences (SSR-IIJLS), 4(3), 766-1773. https://europub.co.uk/articles/-A-670898