Use of Procalcitonin for Optimizing Antimicrobial Therapy in Long Term ICU Patients
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 3
Abstract
Most of the studies are conducted to evaluate the role of procalcitonin in the diagnosis and management of sepsis at the time of admission or in a defined set of patients [Respiratory infection, surgical sepsis, neonatal sepsis, emergency department, burn patients etc]. The aim of the study was to determine the role of serial monitoring of PCT-serum level with the clinical assessment of the patients and guiding the antimicrobial therapy. The study was conducted for two months and all patients admitted to ICU with suspected sepsis, were included in the study. Patient’s demography, SOFA score, APACHE II score and other laboratory parameters were recorded. The blood sample was collected on the day of admission and on alternate days till ten days of admission or discharge from ICU whichever comes earlier. The sera were separated and quantitative estimation of PCT was done by ELISA based technique. In total seven patients were included in the study. The median baseline level of PCT was 135.45 ng/ml higher than the other studies. The baseline level had no correlation with severity of illness. Two of the patients admitted with septic shock succumbed to infection. There was 30% increase in PCT from baseline in these patients. All patients, who improved clinically and transfer out of the ICU and survived showed >10% decrease in PCT. The percent change in PCT started increasing a day before clinical deterioration in one of the patient. Hence percent change in PCT level may be used as a supportive marker while escalating/ de-escalating/ continuing same antimicrobial therapy.
Authors and Affiliations
Shilpee Kumar, Karan Sachdeva, Santhosh Rajan, Monika Matlani
Keywords
Related Articles
- EP ID EP670898
- DOI 10.21276/ijlssr.2018.4.3.5
- Views 94
- Downloads 0
Role of Oxidant Alteration of Biomolecules in Diabetes and Other Associated Diseases
Reactive oxygen species (ROS) are products of normal cellular metabolism and are known to act as second messengers. Physiological conditions, ROS participate in maintenance of cellular ‘redox homeostasis’ in order to pro...
Genotoxic Study of Chewing Leaf Tobacco in Swiss Albino Mice
The tobacco plant Nicotiana has probably been responsible for more deaths than any other herb as it is market driven commodity of economic benefit. While the majority will likely be killed by use of cigarettes, tobacco u...
Seasonal Diversity and Status of Butterfly Fauna in Sakoli Taluka of Bhandara District, Maharashtra, India
Sakoli taluka lies in the basin of Chulbandh river and covered with dense forest and comprises agricultural fields and it is less highlighted for butterflies so the main aim of this study to show how these fields serve b...
First Report on Adedes albopictus Subgroup Species in India- Short Communication
Adedes albopictus is most advanced stable species trophic level. It is acquired by after great nurture microevolution includes behavioral changes and survivality. In this evolutionary cascade, Ae. albopictus species dive...
Day Care Surgery in Tertiary Level Hospital
Day care surgery was started as money saving modality. It has picked up momentum even in India. In last one decade due to innovations in surgical techniques and advances in anaesthesia, the positive feedback from the pat...