Usefulness of Lumipulse Presto Ortho HCV in screening for hepatitis C virus (HCV) infection
Journal Title: Journal of Analytical Bio-Science - Year 2011, Vol 34, Issue 2
Abstract
Hepatitis C virus (HCV) is a causative agent of liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV is transmitted primarily via blood contact such as the contaminated syringes used in the vaccination of school children prior to 1958, as well as blood transfusions vertically transmitted from mother to child, sexual contact, etc. The estimated number of HCV carriers in Japan is 1-2 per 100 residents but 70-80% in patients with chronic hepatitis. Therefore, screening programs using combination tests of HCV antibody, antigen, and nucleic acid testing (NAT) are stillinuse. In this study, we measured HCV antibody levels, i.e., the cut-off index (C.O.I.), by Lumipulse Presto Ortho HCV (Fujirebio Inc, Tokyo, Japan) in 508 sera based on the National Screening and Testing guidelines. The antibody test results were divided into four groups (negative, low-titer, middle-titer and high-titer), in which the rate of concordance was confirmed between a HCV risk assessment by Lumipulse Presto Ortho HCV and assessments by other additional tests. Our results strongly suggest that the HCV carriers would be efficiently detected with Lumipulse Presto Ortho HCV.
Authors and Affiliations
Asuka Tani, Takashi Kakinoki, Hiroshi Ihara, Makoto Suzuki
Keywords
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