Validation of a novel Spectrophotometric methods for estimation of Deferasirox

Abstract

A simple, novel and sensitive spectrophotometric method was developed for the determination of Deferasirox1-3 (DFX) in bulk and in pharmaceutical formulations. The method is based on Reduction of the drug in the presence of ferric chloride, followed by reaction under acidic conditions to produce a purple colored complex that exhibited maximum absorbance at λmax of 530 nm. Beer’s law is obeyed in the concentration range of 10-50 g / ml. Results of analysis were validated statistically and by recovery studies. This method could be successfully employed for the routine quality control analysis of Deferasirox (DFX) in various pharmaceutical preparations, bulk and dosage forms.

Authors and Affiliations

Lalitha Manasa. P* , Shanmukh Kumar J. V. , Vijaya Saradhi. S , Rajesh. V

Keywords

Related Articles

Development and Validation of HPTLC Method for the Simultaneous Estimation of Telmisartan and Ramipril in Combined Dosage Form

This paper describes developed and validated thin layer liquid chromatography (TLC) method for the simultaneous estimation of telmisartan and ramipril in a combined dosage form. Procedure does not require prior separatio...

Evaluation of the Toxic Effects of Clozapine in Zebra fish (Danio rerio) embryos with the Fish Embryo Toxicity Test

Clozapine (an atypical antipsychotic drug) is indicated in treatment-refractory schizophrenia. Antipsychotics have been reported to have cardiotoxic effects in humans.The zebra fish (Danio rerio) is a tropical cyprinid u...

Validation of a novel Spectrophotometric methods for estimation of Deferasirox

A simple, novel and sensitive spectrophotometric method was developed for the determination of Deferasirox1-3 (DFX) in bulk and in pharmaceutical formulations. The method is based on Reduction of the drug in the presence...

DEVELOPMENT AND OPTIMIZATION OF FIXED DOSE ANTIHYPERTENSIVE COMBINATION DRUGS USING DOUBLE LAYER SUSTAINED RELEASE MICROSPHERE TECHNOLOGY

For the development of Double walled microspheres, we have selected polymer: Chitosan and Eudragit E100. The inner core which is made up of polymer chitosan will contain drug; propranolol hydrochloride and outer shell wh...

PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE DIFFERENT EXTRACTS OF TUBER OF AMORPHAPHALLUS PAEONIIFOLIUS (ARACEAE)

The present study was aimed to investigate phytochemicals present in the tuber extract of Amorphaphallus paeoniifolius and development of new solvent system for thin layer chromatography of petroleum ether and ethanol ex...

Download PDF file
  • EP ID EP150314
  • DOI -
  • Views 127
  • Downloads 0

How To Cite

Lalitha Manasa. P*, Shanmukh Kumar J. V. , Vijaya Saradhi. S, Rajesh. V (2011). Validation of a novel Spectrophotometric methods for estimation of Deferasirox. International Journal of Pharmaceutical and Biological Research, 2(1), 1-3. https://europub.co.uk/articles/-A-150314