Validation of a novel Spectrophotometric methods for estimation of Deferasirox
Journal Title: International Journal of Pharmaceutical and Biological Research - Year 2011, Vol 2, Issue 1
Abstract
A simple, novel and sensitive spectrophotometric method was developed for the determination of Deferasirox1-3 (DFX) in bulk and in pharmaceutical formulations. The method is based on Reduction of the drug in the presence of ferric chloride, followed by reaction under acidic conditions to produce a purple colored complex that exhibited maximum absorbance at λmax of 530 nm. Beer’s law is obeyed in the concentration range of 10-50 g / ml. Results of analysis were validated statistically and by recovery studies. This method could be successfully employed for the routine quality control analysis of Deferasirox (DFX) in various pharmaceutical preparations, bulk and dosage forms.
Authors and Affiliations
Lalitha Manasa. P* , Shanmukh Kumar J. V. , Vijaya Saradhi. S , Rajesh. V
Keywords
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