Validation of Analytical Methods for Determination of Methamphetamine Using Fourier Transform Infrared (FTIR) Spectroscopy
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Validation of analytical methods for determination of methamphetamine using Fourier Transform Infrared (FTIR) Spectroscopy has been done. Parameter validation method are the repeatability of the system (precision), accuracy, linear ranges, limit of detection (LOD) and limit of quantification (LOQ). Samples was prepared by mixing a weighed portion of methamphetamine standard and alum and swirled flatly to homogeneous mixture. The mixture with total weighed of powder obtained is approximately 1.0 g. This sample was analysis using FTIR. The results of the study showed that the correlation of determination analysis methamphetamine using FTIR was R 2=0.9998 at functional group with wave length number 698.83 cm-1 . Precision, RSD Horwitz, LOQ, LOD and recovery of the validation of analytical methods for determination of methamphetamine using FTIR were found to be 0.0087%, 2.052%, 2.3035%, 7.6786%, and 104.2%, respectively. This method have uncertainty of measurement is 0.8552%. The final result and uncertainty was (84.3334 ± 0.8552) % of methamphetamine in sample. As a conclusion, the validation of analytical methods for determination of methamphetamine using FTIR is very good method. This method is simplicity of sample preparation and low cost reagents.
Authors and Affiliations
Riyanto1 . , Sri Wulan Nas
Validated Reverse Phase Stability-Indicating Hplc Method for Clofarabine in the Presence of Degradation Products and its Process-Related Impurities.
The study reports simultaneous determination of clofarabine and its related substances of impurities in their pharmaceutical dosage form using validated stability indicating reverse phase high performance liquid chromato...
Phenological Study Of Two Populations Of Cnidoscolusquercifoliuspohl(Faveleira) In Semiarid Region Of Brazil
The phonological patterns of two populations of Cnidoscolus quercifolius Pohl were evaluated in the caatinga biome western Seridó region of Paraiba State, Brazil. Was analysis represented by activity indices for both pop...
Nasal Drug Delivery-A Pre Hospital Therapy in Status EpilepsyReview
Status epileptics is a brain disorder. It is an important neurological emergency with high mortality and morbidity. it causes loss of cerebral autoregulation and neuronal damage. Prompt and immediate prehospital treatmen...
Quantized ATP Production
Although ATP production is very important for mitochondria, little is known about the actual rate of production and the value of “unit of currency” for mitochondrial energy transactions. “Unit of currency” for all transa...
A Study of Anti-inflammatory effect of Heparin and Enoxaparin on Experimentally Induced acute Inflammation in Albino Rats.
Objective: To evaluate and compare anti-inflammatory effect of Heparin and Enoxaparin with the standard drug Diclofenac sodium. Methodology: Rat paw edema induced by carrageenan was the experimental model. Albino rats we...