ЗМІНИ У СИСТЕМІ АСИМЕТРИЧНИЙ ДІМЕТІЛАРГІНІН – ЕНДОТЕЛІАЛЬНА NO-СИНТАЗА У ХВОРИХ НА ГОСТРИЙ ІНФАРКТ МІОКАРДА І ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ
Journal Title: INTERNATIONAL ACADEMY JOURNAL "Web of Scholar" - Year 2018, Vol 2, Issue 2
Abstract
Background. The role of asymmetric dimethylarginine (ADMA) in patients with acute myocardial infarction (AMI) and diabetes mellitus (DM) type 2 remains an understudied area. The aim of research is the assessment of asymmetric dimethylarginine and its links with carbohydrate and lipid metabolism parameters in patients with acute myocardial infarction and type 2 diabetes mellitus following determination of plasma levels of asymmetric dimethylarginine and NO synthase. Materials and methods. The study involved examination of 73 patients with AMI and DM type 2, 57 patients with AMI and without DM type 2 and 20 substantially healthy subjects. The content of ADMA was established by enzyme-immunoassay using the commercial test system of Immunodiagnostik company ADMA Xpress ELISA Kit (Austria). The content of NO synthase was established by enzyme-immunoassay using the commercial test system of Bender MedSystem (Austria). Carbohydrate and lipid parameters were determined by standard biochemical method. Results and discussion. The study provided a possibility to determine a direct correlation between ADMA and total cholesterol (r=0.47, p<0.05); LDL cholesterol (r=0.28, p<0.05), HDL cholesterol (r=-0.39, p<0.05), triglycerids (r=0.35, p<0.05), glucose (r=0.46, p<0.05), insulin (r=0.49, p<0.05), glycosylated hemoglobin (r=0.39, p<0.05). Correlation analysis showed a reverse relationship between the level of ADMA and NO synthase (r=-0.54, p<0.05).
Authors and Affiliations
Д. В. Мінухіна, В. Д. Бабаджан, П. Г. Кравчун
Keywords
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