Journal of Biomedical and Pharmaceutical Research

Journal of Biomedical and Pharmaceutical Research

Basic info

  • Publisher: Journal of Biomedical and Pharmaceutical Research
  • Country of publisher: india
  • Date added to EuroPub: 2017/May/09

Subject and more

  • LCC Subject Category: Biomedicine, Pharmacology
  • Publisher's keywords: Biomedical, Pharmacology, Therapeutic
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 1500 INR
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2012
  • Does the author retain unrestricted copyright? True
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: LOCKSS
  • Deposit policy registered in: None

This journal has '463' articles

Cervical Cancer–A Review Article

Cervical Cancer–A Review Article

Authors: Gunjan Jadon*| Shrinathji Institute of Pharmacy, Nathdwara-313301 Rajsamand (Raj), India., Keyur Sanjaykumar Joshi| Shrinathji Institute of Pharmacy,...
( 44 downloads)
Abstract

Cervical Cancer is malignant Carcinoma type of cancer originate in cervix region. The cervix is the narrow portion of the uterus where it joins with the top of the vagina. Most cervical cancers are squamous cell carcinomas, arising in the squamous (flattened) epithelial cells that line the cervix. Adenocarcinoma, arising in glandular epithelial cells is the second most common type. Very rarely, cancer can arise in other types of cells in the cervix. Cancer refers to a class of diseases in which a cell or a group of cells divide and replicate uncontrollably, intrude into adjacent cells and tissues (invasion) and ultimately spread to other parts of the body than the location at which they arose (metastasis) (National Cancer Institute 2009). In cervical cancer, (cancer of the uterine cervix), cancer develops in the tissues of the cervix, which is a part of the female reproductive system. The cervix connects the upper body of the uterus to the vagina. The endocervix (the upper part which is close to the uterus) is covered by glandular cells, and the ectocervix (the lower part which is close to the vagina) is covered by squamous cells. The transformation zone refers to the place where these two regions of the cervix meet (American Cancer Society 2009).

Keywords: Types of Cervical Cancer, Etiology, Symptoms, Treatment, Prevention
Holistic Molecular Approaches for Anticancer Therapy

Holistic Molecular Approaches for Anticancer Therapy

Authors: Dr. Gousia Chashoo*| Pharmacology Division, Indian Institute of Integrative Medicine, canal road, Jammu., Dr. Shashank K Singh| Pharmacology Division,...
( 35 downloads)
Abstract

Cancer is a threat concomitant with human history. Although we have stepped into the very advanced twenty first century with considerable progress in cancer treatment, it is still a very difficult disease to treat and is the second most common disease that causes mortality. In recent years, the discovery of new anticancer drugs has evolved from a dramatic shift from cell based screening for anti proliferative effects to a more mechanistically based approach that targets the specific molecular lesions thought to be responsible for the development and maintenance of the malignant phenotype in various forms of cancer. The development of molecularly targeted drugs has improved the efficacy and selectivity of cancer treatment by exploiting the differences between cancer cells and normal cells. Targeted therapies are now a component of treatment for many types of cancer, including breast, colorectal, lung and pancreatic as well as lymphoma, leukemia and multiple myeloma. In order to enhance the specificity and efficacy of current cancer therapies, the aim of this review is to shed light on some of the important molecular targets.

Keywords: Cancer, Apoptosis, Cell signalling, Therapeutic targets
Formulation and Evaluation of Pluronic lecithin organogel of Flurbiprofen

Formulation and Evaluation of Pluronic lecithin organogel of Flurbiprofen

Authors: Choukse R.*| Suresh Gyan Vihar University, Jaipur, Rajasthan, India., Sangameswaran B| Adesh Institute of Pharmacy & Biomedical Sciences, Bathinda, Pu...
( 29 downloads)
Abstract

The aim of the present work was to generate an index to predict topical ef®ciency of a series of nonsteroidal anti-in¯ammatory drugs Organogel, a viscoelastic system, can be regarded as a semi-solid preparation which has an immobilized external apolar phase. The apolar phase gets immobilized within spaces of the three-dimensional networked structure formed due to the physical interactions amongst the selfassembled structures of compounds regarded as gelators. In general, organogels are thermodynamically stable in nature and have been explored as matrices for the delivery of bioactive agents. In the current manuscript, attempts have been made to understand the properties of organogels, various types of organogelators and some applications of the organogels in controlled delivery.

Keywords: Organogel, Gel, Gelator, Drug delivery, Biocompatibility
X-Ray Characterisation of Various Aluminium Phases in the Medicinal Herb Bacopa Monnieri Affected by Simulated Acid Rain

X-Ray Characterisation of Various Aluminium Phases in the Medicinal Herb Bacopa Monnieri Affected by Simulated Acid Rain

Authors: S. Behera| Department of Environmental Science, Sambalpur University, Jyoti Vihar- 768019, India, B. Mallick*| Institute of Physics, Sachivalay Marg,...
( 29 downloads)
Abstract

In the present investigation various aluminium-based new phases formed due to substitution of sulphur via simulated acid rain in Bacopa monnieri have been analyzed using X-ray diffraction (XRD) technique. So far there is no report on the effects of acid rain on the B. monnieri herb and its vital properties like memory-boosting mechanism. Therefore, in the present study, an attempt has been made to analyze the various aluminium phase (salt) formations due to the substitution of sulphur via simulated acid rain (SiAR) in B. Monnieri because of its toxicological importance. The new phases like AlH(SO4)2 and Al2S3 along with usual Al2O3:H2O, MgO, FeAl2(PO4)2(OH)2:8H2O, (K2Ca(SO4)2:H2O), have been observed in B. monnieri when treated with sulphuric-simulated acid rain (S-SiAR) of two different pH (3.39 and 5.45) for 20 weeks. These Al-based new salts formed in the above medicinal herb due to the induction of S-SiAR may cause Alzheimer’s disease and induce other abnormities.

Keywords: Sulphuric-simulated acid rain, X-ray diffraction, Bacopa monnieri, phases, pH
Effect of Orange (Citrus sinensis) Peel Oil on Lipid Peroxidation, Catalase activity and Hepatic Biomarker levels in Blood Plasma of Normo Rats

Effect of Orange (Citrus sinensis) Peel Oil on Lipid Peroxidation, Catalase activity and Hepatic Biomarker levels in Blood Plasma of Normo Rats

Authors: Ochuko L. Erukainure*| Food Technology Division, Federal Institute of Industrial Research, Lagos, Nigeria, John A. Ajiboye| College of Natural and App...
( 31 downloads)
Abstract

Dietary antioxidants are considered beneficial because of their potential protective role against oxidative stress, which is involved in the pathogenesis of multiple diseases such as cancer and coronary heart disease. The effect of feeding orange peel oil on lipid peroxidation, catalase and hepatic biomarkers in blood plasma of normo rats was investigated. Beside mouse chow, four diets were designed to contain 50% of energy as carbohydrate, 35% as fat, and 15% as protein, and one that was lipid-free diet which had distilled water substituted for fat. Groups of five rats were each fed one of these diets, while a fifth group was fed pelletized mouse chow. There was no significant difference in the amount of food consumed, though significant weight lost was observed in all groups except soybean oil. Feeding on orange peel oil led to significant (p<0.05) decrease in lipid peroxidation and catalase activities in comparison to soybean oil. Higher AST and lower ALT activities were observed in orange peel oil fed groups. These results suggest the oil from the orange peels possesses antioxidant potentials which could be protective against oxidative stress, thus useful in its treatment and management. However, the elevated levels of hepatic biomarkers pose a threat of hepatotoxicity thus suggesting that it should be consumed or used as a pharmaceutical ingredient at lower concentrations.

Keywords: Orange peel oil, Lipid peroxidation, Catalase, Hepatotoxicity
Laboratory Assessment and Phytochemical Screening of Mollugo spergula

Laboratory Assessment and Phytochemical Screening of Mollugo spergula

Authors: Sagar Naskar*| Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata, India-Bengal College of Pharmaceutical Sciences and Research, Durgapu...
( 29 downloads)
Abstract

Medicinal plants are used for the treatment of various ailments especially in India due to its traditional systems and wide biodiversity. Less than 5% of the Indian medicinal flora has been evaluated systematically till date indicating a vast untapped potential midst of the global opportunity. The aim of the present study is the laboratory assessment and phytochemical screening of Mollugo spergula. The methanol extract of Mollugo spergula contains 3.67 μg of β-carotene and 33.9 μg of lycopene, 9.23 mg of Vitamin C per g of the extract. The extract contains polyphenols viz.14.51 μg of pyrocatechol and 2.91 μg of gallic acid per g of the extracts. From the present study it has been found that the Mollugo spergula is enriched with valuable phytoconstituents having antioxidant activity. Further studies are going on in our laboratory to evaluate its wider biological activity.

Keywords: Mollugo spergula, Phytoconstituents, Lycopene, Vitamin C, Polyphenols
Transdermal Delivery of Bisoprolol Hemifumarate

Transdermal Delivery of Bisoprolol Hemifumarate

Authors: Mohamed A. El-Nabarawi*| Pharmaceutics and Industerial Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Saadia A. Tayel| Pha...
( 30 downloads)
Abstract

The aim of this study was to formulate and evaluate the administration of bisoprolol hemifumarate (BH) using transdermal delivery systems. The following formulae were prepared as a reservoir to be used in batch formulae. Gels: carbopol 934 and carbopol 940 (C.934 and C.940); each in three different concentrations was prepared. In addition, emulgels were prepared and thermo sensitive gels utilizing Pluronic F127 (P.F127). The physicochemical properties of the drug were characterized by determining the partition coefficients. Subsequently, the prepared formulae were evaluated according to their rheological properties, in vitro release using a USP dissolution tester, in vitro diffusion using Franz's diffusion cells and bioavailability (studied in albino rabbits). All the formulae were manifested as pseudoplastic flow with thixotropy. In general, the viscosity of the prepared formulae increased with increasing the polymer concentrations, and this led to a decline in the percentage of the drug released. From all the formulae that were tested, pluronic F127 gave the highest drug concentration in rabbits (The highest Cmax and the lowest Tmax) in comparison to the other formulae and the oral commercial formulae. So, transdermal application of 20 % (w/w) P.F127 gel containing 0.5% w/w BH can be a promising new dosage form for treatment hypertension and angina pectoris. The significant findings presented here encourage further studies.

Keywords: Bisoprolol hemifumarate, transdermal delivery systems, diffusion test, release study, bioavailability study
Invention of Analgesic and Anti-Inflammatory Activity of Ethanolic Extract of Mimosa Pudica Linn Leaves.

Invention of Analgesic and Anti-Inflammatory Activity of Ethanolic Extract of Mimosa Pudica Linn Leaves.

Authors: Dr. Chandrashekar D. K.*| Department of Microbiology, MRMC, Gulbarga, Dr. Deepak M. Manthale| Department of Microbiology, MRMC, Gulbarga
( 29 downloads)
Abstract

The ethanolic extract of the leaves of Mimosa pudica at the doses of 200 and 400mg/kg was tested for anti-inflammatory and analgesic activity. The extract produced dose dependent and significant inhibition of carrageenan induced paw oedema.The analgesic activity was found to be more significant on the acetic acid induced writhing model (p<0.001) than the tail flick model (p<0.001). So the extract inhibits predominantly the peripheral mechanism. The presence of flavonoids in the ethanolic extract may be contributory to its analgesic and anti-inflammatory activity.

Keywords: Anti-inflammatory, analgesic activity, Aspirin, Ibuprofen, Mimosa pudica
Hypolipidemic Activity of Spinacia Oleracea L. in Atherogenic Diet Induced Hyperlipidemic Rats.

Hypolipidemic Activity of Spinacia Oleracea L. in Atherogenic Diet Induced Hyperlipidemic Rats.

Authors: Ranjan Kumar Giri*| Institute of Pharmacy and Technology, Salipur, Cuttack – 754202, India., Sunil Kumar Kanungo| Institute of Pharmacy and Technology...
( 36 downloads)
Abstract

Spinacia oleracea (spinach) of family Amaranthaceae is an important plant used traditionally for medicinal purposes. Hyperlipidemia was induced by treated orally with atherogenic diet. In atherogenic diet induced hyperlipidemic model, the rats receiving Spinacia oleracea powder showed significant reduction in total cholesterol, triglycerides, total protein and elevation of high density lipoprotein cholesterol. Spinacia oleracea was found to possess significant hypolipidemic activity. The results also suggest that Spinacia oleracea powder at 200mg and 400 mg/kg b.wt. concentrations are an excellent lipid-lowering agent.

Keywords: Cholesterol, Spinacia oleracea, Hyperlipidemic, Triglyceride
Nanoparticle Based Drug Delivery System: Milestone for Cancer Therapy

Nanoparticle Based Drug Delivery System: Milestone for Cancer Therapy

Authors: Dr. Gousia Chashoo| Pharmacology Division, Indian Institute of Integrative Medicine, canal road, Jammu., Dr. Shashank K Singh| Pharmacology Division,...
( 29 downloads)
Abstract

The challenge of modern drug therapy is the optimization of the pharmacological action of the drugs coupled with the reduction of their toxic effects in vivo. The prime objectives in the design of drug delivery systems (DDS) are the controlled delivery of the drug to its site of action at a therapeutically optimal rate and dosage to avoid toxicity and improve the drug effectiveness and therapeutic index. DDS has improved many of the pharmacological properties of conventional ("free") drugs including particulate carriers which are primarily composed of lipids and/or polymers and their associated therapeutics. It alters the pharmacokinetics (PK) and biodistribution (BD) of the associated drugs or functions as drug reservoir or both. Nanoparticles provide a range of new opportunities to increase the targeting of currently approved diagnostic and therapeutic agents to cancers. Nanoparticles carrying a chemotherapeutic can reduce the undesirable distribution of such agents. The problems related to cancer chemotherapy can partially be overcome by direct intratumoral delivery of controlled release biodegradable nanoparticles (NPs).

Keywords: Nanotechnology, Cancer, Drug Delivery System, Nanoparticles
First title: Ionic liquids-useful reaction green solvents for the future Second title: ionic liquids are the replacements for environmentally damaging solvents in a wide range of chemical processes.

First title: Ionic liquids-useful reaction green solvents for the future Second title: ionic liquids are the replacements for environmentally damaging solvents in a wide range of chemical processes.

Authors: G. K. Sudhakar| Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576104, K.Vijaya Bhaskar*| Department of P...
( 32 downloads)
Abstract

Ionic liquids (IL) represent fascinating new class of solvents with unusual physical and chemical properties; low melting salts (up to 1000C). The main driving force for research in this area is the need to find replacement for environmentally damaging solvents in a wide range of chemical processes. To date, most chemical reactions have been carried out in molecular solvents. For the past twenty years, most of our understanding of our chemistry has been based upon the behavior of molecules in the solution phase in molecular solvents. Recently a new class of solvents has emerged called as Ionic liquids. An ionic liquid is an organic salt in which the ions are poorly coordinated, which results in these solvents being liquid below 100°C, or even at room temperature (room temperature ionic liquids, RTIL's). At least one ion has a delocalized charge and one component is organic, which prevents the formation of a stable crystal lattice. Ionic liquids are composed entirely of ions. For example, molten sodium chloride is an ionic liquid; in contrast, a solution of sodium chloride in water (a molecular solvent) is an ionic solution. The term “ionic liquids” has replaced the older phrase “molten salts” (or “melts”), which suggests that they are high-temperature, corrosive, viscous media (like molten minerals). The reality is that ionic liquids can be liquid at temperatures as low as –96°C. Furthermore, room-temperature ionic liquids are frequently colourless, fluid, and easy to handle. In the patent and academic literature, the term “ionic liquids” now refers to liquids composed entirely of ions that are fluid around or below 100°C1. Properties, such as melting point, viscosity, and solubility of starting materials and other solvents, are determined by the substituents on the organic component and by the counter ion. Many ionic liquids have even been developed for specific synthetic problems. For this reason, ionic liquids have been termed "designer solvents”. This means that their properties can be adjusted to suit the requirements of a particular process. Properties such as melting point, viscosity, density, and hydrophobicity can be varied by simple changes to the structure of the ions. For example, the melting points of 1-alkyl-3-methylimidazolium tetrafluoroborates and hexafluorophosphates are a function of the length of the 1-alkyl group, and form liquid crystalline phases for alkyl chain lengths over 12 carbon atoms. Another important property that changes with structure is the miscibility of water in these ionic liquids. For example, 1-alkyl-3-methylimidazolium tetrafluoroborate salts are miscible with water at 25 °C where the alkyl chain length is less than 6, but at or above 6 carbon atoms, they form a separate phase when mixed with water. This behaviour can be of substantial benefit when carrying out solvent extractions or product separations, as the relative solubility’s of the ionic and extraction phase can be adjusted to make the separation as easy as possible. In addition, ionic liquids have practically no vapour pressure which facilitates product separation by distillation. There are also indications that switching from a normal organic solvent to an ionic liquid can lead to novel and unusual chemical reactivity. This opens up a wide field for future investigations into this new class of solvents in catalytic applications. Research into ionic liquids is booming. The first industrial process involving ionic liquids was announced in March 2003, and the potential of ionic liquids for new chemical technologies is beginning to be recognized. One of the primary driving forces behind research into ionic liquids is the perceived benefit of substituting traditional industrial solvents, most of which are volatile organic compounds (VOCs), with non-volatile ionic liquids. Replacement of conventional solvents by ionic liquids would prevent the emission of VOCs, a major source of environmental pollution. Ionic liquids are not intrinsically “green”—some are extremely toxic—but they can be designed to be environmentally benign, with large potential benefits for sustainable chemistry. There are four principal strategies to avoid using conventional organic solvents: No solvent (heterogeneous catalysis), water, supercritical fluids, and ionic liquids. The solventless option is the best established, and is central to the petrochemical industry, the least polluting chemical sector. The use of water can also be advantageous, but many organic compounds are difficult to dissolve in water, and disposing of contaminated aqueous streams is expensive2. Supercritical fluids, which have both gas- and liquid-like properties, are highly versatile solvents for chemical synthesis. This technology was recently commercialized by Thomas Swan & Co., Ltd., in a chemical plant designed for multipurpose synthesis. Together with ionic liquids, these alternative solvent strategies (sometimes referred to as alternative reaction media or green solvents) provide a range of options to industrialists looking to minimize the environmental impact of their chemical processes. What are the advantages of using a room-temperature ionic liquid in an industrially relevant catalytic process? As noted above, ionic liquids have no detectable vapour pressure, and therefore contribute no VOCs to the atmosphere. But this is not the only reason for using ionic liquids. Another is that at least a million binary ionic liquids, and 1018 ternary ionic liquids, are potentially possible3. (For comparison, about 600 molecular solvents are in use today.) The next decade should see ionic liquids being used in many applications where conventional organic solvents are used today. Furthermore, ionic liquids will enable new applications that are not possible with conventional solvents. In the future, solvents will be designed to control chemistry, rather than the chemistry being dictated by the more limited range of molecular solvents currently used4. As discussed above, Ionic liquids are salts consisting of cations such as imidazolium, pyridinium, quarternary ammonium and quarternaryphosphonium, and anions such as halogen, triflate, trifluoroborate and hexafluorophosphate, which exists in the liquid state at relatively low temperatures. Their characteristic features include almost no vapour pressure, non-inflammability, non-combustibility, high thermal stability, relatively low viscosity, wide temperature ranges for being liquids and ionic liquid conductivity.

Keywords: ionic liquids, green solvents, designer solvents, low melting salts
Development of Stability-Indicating Liquid Chromatographic Method for Analysis of Cefoxitin Sodium in Sterile Formulation.

Development of Stability-Indicating Liquid Chromatographic Method for Analysis of Cefoxitin Sodium in Sterile Formulation.

Authors: R. Revathi*| Dept of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode - 638112, Tamil Nadu,, N. Reddiyar Lisha| Dept of Pharmaceutical An...
( 37 downloads)
Abstract

Stability-indicating high performance liquid chromatography (HPLC) method was developed and validated for analysis of cefoxitin sodium in its powder for injection dosage form. Chromatographic separation was achieved on a C18 µBondapack (300×3.9, 10µ) column, maintained at 30°C with a mobile phase consisted of water: acetonitrile: glacial acetic acid (800:190:10) and a flow rate of 0.9mL/min. The peak was detected at 254nm & the retention time was obtained at 16.74 min. The peak area plot was linear over the concentration range of 72.16µg/mL to 451.04µg/mL. The different experimental parameters affecting the drug stability were optimized. The method was validated for accuracy, precision, reproducibility, specificity, robustness and ruggedness in accordance with International Conference on Harmonization (ICH) guidelines. The proposed method was successfully applied for the analysis of cefoxitin sodium in drug substance and drug product in the presence of hydrolytic and oxidative degradants.

Keywords: Cefoxitin sodium, Degradation, Stress condition, Stability-indicating
Relaxant Effects of Syzygium Cumini Leaves on Guinea Pig Tracheal Chains and its Possible Mechanism(s)

Relaxant Effects of Syzygium Cumini Leaves on Guinea Pig Tracheal Chains and its Possible Mechanism(s)

Authors: P. K Mahapatra*| Pharmacology Division, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha, India., D. Pradhan| P...
( 35 downloads)
Abstract

The leaves of Syzygium cumini is an attractive leaves of myrtaceae family . The purpose of this study was investigating experimentally the possible anti asthma activity of macerated and soxhlet extracts of leaves of this plant on tracheal chains of guinea pigs were evaluated. The relaxant effects of 4 cumulative concentrations of macerated and soxhlet extracts (0.25, 0.5, 0.75 and 1.0 W/V) in comparison with saline as negative control and 4 cumulative concentrations of theophylline (0.25, 0.5, 0.75, and 1.0 mM) as positive control were examined on precontracted tracheal chains of two groups of 6 guinea pig by 60 mM KCl (group 1, N=6) and 10 µM methacholine the non-incubated tissues (group 2, N = 6) and tissues incubated with 1 µM propranolol (group 3, N = 4) [15]. Decrease in contractile tone of tracheal chains was considered as relaxant effect. The isolated guinea-pig trachea pre-contracted with KCl, methacholine and tissues incubated with propranolol were used to study the relaxation of macerated and soxhlet extracts of leaves Syzygium cumini. In group 1 experiments only the last one higher concentrations of theophylline and soxhlet extract showed significant relaxant effect compared to that of saline (p<0.001 for both concentrations), which were significantly greater than those of macerated extracts (p<0.001 for all cases).In group 2 experiments only the last two higher concentrations of theophylline and soxhlet extract showed significant relaxant effect compared to that of saline. The effects of two higher concentrations of theophylline in this group were significantly greater than those of macerated and soxhlet extracts (P < 0.01). And in group 2 and 3 experiments both macerated and soxhlet extracts showed concentration-dependent relaxant effects compared to that of saline (p<0.05 to p<0.001 for both extracts).The relaxant effects of macerated and soxhlet extracts in group 1 were significantly lower than those of groups 2 and 3.In group 3 experiment potent relaxant effect was observed.

Keywords: Syzygium cumini, Bronchodilatory Guinea pig, Trachea
Method Development and Validation of Montelukast in Bulk and Pharmaceutical Dosage form by RP-HPLC

Method Development and Validation of Montelukast in Bulk and Pharmaceutical Dosage form by RP-HPLC

Authors: Minaketan Sahoo*| Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India-754202, B V V Ravi Kumar| Roland institute of pharmaceutical s...
( 30 downloads)
Abstract

The present work describes a simple, precise and accurate HPLC method for estimation of montelukast sodium in bulk and in tablet dosage form. Montelukast sodium is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene (CysLT1) receptor. The separation was achieved by using Waters symmetry shield RP-C8 column and acetonitrile: sodium di-hydrogen Phosphate dehydrate (pH 3.7) in proportion of 70:30 v/v as mobile phase, at a flow rate of 1.5 ml/min. Detection was carried out at 225 nm. The retention time of montelukast sodium was found to be 3.721 min. The limit of detection was found 0.1357 µg/ml and limit of quantification 0.4111 µg/ml. The accuracy and reliability of the proposed method was ascertained by evaluating various validation parameters like linearity (1-30 µg/ml), accuracy, precision, robustness and specificity according to ICH guidelines. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining Montelukast in bulk or in pharmaceutical dosage forms.

Keywords: Montelukast, High Performance Liquid Chromatography, Method development, Validation
Studies on Gastroselective Famotidine Floating Tablets for Gastric Ulcers and Effect of Polymeric Excipients on Drug Release.

Studies on Gastroselective Famotidine Floating Tablets for Gastric Ulcers and Effect of Polymeric Excipients on Drug Release.

Authors: Putta Rajesh Kumar*| Department of Pharmaceutics and Pharmaceutical chemistry, V.L.College of Pharmacy, Raichur, Karnataka, India., Shamsheer Ahmad S|...
( 31 downloads)
Abstract

The present investigation was planned to formulate effervescent floating, gastroretentive guar gum tablets containing famotidine, which can be useful in the treatment of gastric ulcer. The investigations carried out on various formulations resulted in totally four formulations obeying zero order kinetics. The study on rheological characteristics of powder bed indicated that, all the granules were freely flowing and compressible; density of all the tablets was less than 1, thereby assisting in floating of the dosage form on the surface of the simulated gastric fluids in vitro. Studies on compression characteristics indicated that, the tablets float over the surface and remain over the surface for a period of more than 10 h, except FS and FS1, which stay over the surface little lesser time than other tablets. Drug content was fairly uniform and consistent. The floating guar gum tablets containing HPMC K4M and Xanthan gum as binders follow zero order drug release kinetics. The increasing the amounts of magnesium stearate does not significantly alter the drug release kinetics; it improves the flowability of the granule bed. Tablets swell when in contact with water and the swelling index is highest with xanthan gum gel followed by the order, followed by FH> FX1> FC>FH1> FC1>FS>FS1. Stability studies at 45ºC and 75 % RH indicates that there is decrease in drug content, amounting to 30%, when observed for a period of 3 months.

Keywords: Famotidine, Effervescent gastroretentive tablet, Release kinetics, Stability studies

About Europub

EuroPub is a comprehensive, multipurpose database covering scholarly literature, with indexed records from active, authoritative journals, and indexes articles from journals all over the world. The result is an exhaustive database that assists research in every field. Easy access to a vast database at one place, reduces searching and data reviewing time considerably and helps authors in preparing new articles to a great extent. EuroPub aims at increasing the visibility of open access scholarly journals, thereby promoting their increased usage and impact.