Universal Journal of Pharmaceutical Research

Universal Journal of Pharmaceutical Research

Basic info

  • Publisher: UJPR
  • Country of publisher: india
  • Date added to EuroPub: 2019/Feb/24

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Pharmacognosy and Phytochemistry, Biopharmaceutics, Pharmaceutical Analysis, Pharmaceutical Microbiology, Pharmaceutical Biotechnology, Pharmacology and Toxicology, Clinical Pharmacy, Bioinformatics, Pharmaceutical Management, Health Care Management, Hospital Management, Biochemistry, Regulatory Affairs
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 100 USD
  • Submission charges: No
  • Waiver policy for charges? Yes

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '151' articles

TOLNAFTATE LOADED LIPOSOMES- DESIGN, AND IN-VITRO EVALUATION

TOLNAFTATE LOADED LIPOSOMES- DESIGN, AND IN-VITRO EVALUATION

Authors: Dingwoke Francis John, Unus A A, Udokwu Japheth Chigbo, Ugwoke Sunday Paul, Ezeaku Ikenna
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Abstract

Liposomes are colloidal particles formed as concentric bimolecular layers that are capable of encapsulating drugs. Liposomes have the potential for extending the duration of action for days or months. Tolnaftate is used as the topical antifungal agent. The purpose of this study was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability. In present study, four different liposomes formulations of Tolnaftate were prepared by ethanol (solvent) injection method by varying the concentrations of phospholipids. The prepared liposomes were characterized for size, shape, entrapment efficiency, zeta potential, in-vitro drug release. An in vitro drug release of about 82.114 % in 10 h was observed from optimum formulation of batch LS4.

Keywords: Entrapment efficiency, in-vitro drug release, liposomes, phospholipid, Tolnaftate, zeta potential
PRODUCT RECALL: A COMMENTARY ON RISING INCIDENCES

PRODUCT RECALL: A COMMENTARY ON RISING INCIDENCES

Authors: Viney Chawla, Manish Pal Singh, Manish Kumar
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Abstract

There has been an increasing trend in the number of prescribed and over-the-counter drug recall over the last few years. The recall is usually due to company's discovery, customer's complaint or Food and Drug Administration (FDA) observation. The process of recall involves a planned specific course of action, which addresses the depth of recall, need for public warning, and the extent of effectiveness checks for the recall. The FDA review and/or recommend changes to the firm's recall strategy, as appropriate. The critical recall information list includes the identity of the product; summary of the failure; amount of product produced in the distribution chain and direct account. Product recalls clashes thousands of companies every year affecting: sales, testing customer relationships and disrupting supply chains. Drug recall is incubus for pharmaceutical companies. It effects the reputation of the company. The reason for the recall can be divided into two categories: manufacturing related and safety/efficacy related. It is essential to follow all the guidelines related to drug development and manufacturing procedure to minimize drug recall.

Keywords: Drug product recall, guidelines, process, recall information
MURRAYA KOENIGI-A BOON IN DIFFERENT PATHOLOGICAL CONDITIONS

MURRAYA KOENIGI-A BOON IN DIFFERENT PATHOLOGICAL CONDITIONS

Authors: Igwe J. Chibueze, Emenike I V
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Abstract

Since very long period of time medicinal plants or their bioactive compounds have been utilized by majority of world population particularly in developing countries for primary and traditional healthcare system. At present scenario, people are more interested to use herbal drugs because they are considered as safe and inexpensive having no adverse effects. Different parts of the plants like roots, leaves, stem, bark, fruits and seeds have been used in treatment of different diseases and strengthening the immune system. Murraya koenigii, is a herb from mainly Asian origin, it has therapeutic applications such as in bronchial disorders, piles, vomiting, skin diseases, night blindness, dysentery, diarrhoea, bites of poisonous animals, bruises and eruption etc. The present review is an attempt for description of M. koenigii, its phytochemical constituents and various pharmacological activities.

Keywords: Murraya koenigii, phytochemistry, pharmacological activities
Message.

Message.

Authors: Felix Sunday Yusuf
Message. 2019/Feb/24
( 0 downloads)
Abstract

''It’s been an inspiring journey serving as the Managing Editor of the Universal Journal of Pharmaceutical Research (UJPR) and I have all the editors, contributors and authors to thank for it. Universal Journal of Pharmaceutical Research, as a specialty journal is a double blind peer-reviewed informational journal that provides rapid publication (bi-monthly) of original research papers, scientific commentaries, views and review articles, and editorial commentary in the gamut of pharmaceutical sciences. It is no secret that the landscape of scholarly publishing is quickly changing, getting more innovative. Across disciplines, new demands and expectations from both authors and readers (visitors) have encouraged shifting perspectives and strategies among editors and publishers. Our primary goal as a team is to ensure that The Universal Journal of Pharmaceutical Research remains flexible and innovative in attending to the rapidly shifting scientific communication landscape, while also maintaining and intensifying the high standards and best practices for which the journal is known. Our journey so far has been encouraging, aligning with our mission and tending towards our vision, comprising of review articles and outstanding and translational research in the field of pharmaceutical science and technology. Our editorial board ensure top notch manuscripts are accepted for publication through rigorous double blind peer review process, manned by the editors and a panel of strictly chosen experts in the field. Furthermore, the open access provides has been a rewarding strategy as UJPR finds it a considerable advantages over conventional journals of pharmaceutical sciences with greater visibility and impact. The journal welcomes publications of high quality papers on theoretical and practical applications in pharmaceutical science and technology. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publication. By steadily introducing initiatives to the editorial and review processes, I believe The Universal Journal of Pharmaceutical Research (UJPR) will further develop as a flagship for communicating pharmaceutical research and related field, all while successfully meeting the evolving needs of its audience. I congratulate all editorial board members and authors for their efforts and believe for great success of Universal Journal of Pharmaceutical Research.''

Keywords: Message
IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE

IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE

Authors: Fatima A. Adamude, Moh Kingsley Onyekachi
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Abstract

Diarrhoeal disease is responsible for mortality and morbidity, especially among children in developing countries causing a major healthcare problem. The purpose of the present study was to evaluate anti-diarrhoeal effects of methanolic extract of whole plant of Bombax buonopozense against castor oil-induced diarrhoea model and small intestine transit model in rats. Small intestinal transit models in rats.the number of droppings and the distance traveled by charcoal in intestine were measured. Loperamide (2.5 mg/kg) was used as standard drug, and it has shown significant reductions in fecal output and frequency of droppings whereas extract at the doses of 200 and 400 mg/kg reduced the castor-oil induced frequency and consistency of diarrhoea. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrhoeal agent.

Keywords: Antidiarrhoeal activity, Bombax buonopozense, castor oil induced
DEVELOPMENT AND EVALUATION OF NANOEMULSION FORMULATIONS FOR IMPROVED ORAL DELIVERY OF CARVEDILOL

DEVELOPMENT AND EVALUATION OF NANOEMULSION FORMULATIONS FOR IMPROVED ORAL DELIVERY OF CARVEDILOL

Authors: Edenta Chidi, Ezeaku Ikenna N, Adamu Zainab, Dingwoke Francis John
( 0 downloads)
Abstract

The aim of the present investigation was to develop, optimize and evaluate nanoemulsion system of carvedilol to improve its solubility, and oral bioavailability. Carvedilol is a non-selective beta blocker used in the treatment of mild to moderate congestive heart failure and mild to moderate essential hypertension. It has both poor water solubility (0.583 mg/L) and oral bioavailability (23%) because of significant first-pass hepatic metabolism. Based on solubility testing, clove oil was used as oil, tween 20 was used as surfactants and PEG 400 was used as cosurfactants in construction of phase diagrams. Carvedilol nanoemulsions were prepared by aqueous phase titration method. Out of twelve formulations, eight thermodynamically stable formulations were selected for preparation of carvedilol loaded nanoemulsions and these nanoemulsions were subjected for characterization i.e. particle size, viscosity, polydispersity, zeta potential. A 12 hrs in-vitro release release study was performed on selected nanoemulsion formulations of carvedilol. Study concludes, nanoemulsion formulation of batch NEC4 (Smix ratio 1:3) was found to be optimum formulation.

Keywords: Bioavailability, Carvedilol, first-pass hepatic metabolism, nanoemulsion
FABRICATION AND CHARACTERIZATION OF EZETIMIBE SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT

FABRICATION AND CHARACTERIZATION OF EZETIMIBE SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT

Authors: Usman Mohammed Jajere, Achadu A E
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Abstract

The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to improve the solubility and dissolution rate to facilitate faster onset of action. Ezetimibe is a poorly water soluble BCS class II drug and used as a hypolipidemic agent. It has poor bioavailability (35-65%) due to its low dissolution profile in gastro intestinal tract. In the present study, eight solid dispersion formulations of Ezetimibe with polymers PEG-4000 and PEG-6000 were prepared by solvent evaporation and fusion methods. Solid dispersion formulations were characterized by content uniformity, flow properties and in vitro dissolution studies. Present study concluded that the Ezetimibe solid dispersion formulations are a suitable approach to improve the solubility and dissolution rate of ezetimibe than pure form of drug.

Keywords: Ezetimibe, PEG-4000, PEG-6000, solid dispersion
DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM

DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM

Authors: Saifullahi Umar, Moh Kingsley Onyekachi
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Abstract

The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to Transdermal drug delivery systems deliver the drug through the skin at controlled rate to the systemic circulation. It maintains the blood concentration of the drug within the therapeutic system window ensuring that drug levels neither fall below the minimum effective concentration nor exceed the minimum toxic dose. The objective of the present work was to formulate transdermal gel of Lornoxicam. It is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, HPMC K100 and EC as polymers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability. In–vitro release study was performed for 10 hrs. Selected formulation was subjected to stability testing at different temperatures.

Keywords: Lornoxicam, transdermal gel, pH, viscosity, spreadability in-vitro release, stability studies
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOLE BASED COMPOUNDS

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOLE BASED COMPOUNDS

Authors: Bipin Kumar Verma, Sunil Kapoor, Umesh Kumar, Savita Pandey, Priti Arya
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Abstract

Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.

Keywords: Imidazole, biphenyl ethanone, antibacterial activity, antifungal activity
VALIDATION OF HPLC AND UV VISIBLE METHODS FOR FEW SELECTED BLOOD PRESSURE LOWERING DRUGS AND THEIR FORMULATIONS

VALIDATION OF HPLC AND UV VISIBLE METHODS FOR FEW SELECTED BLOOD PRESSURE LOWERING DRUGS AND THEIR FORMULATIONS

Authors: Shahul Hameed M, Jat R K, Indulatha V N
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Abstract

A simple, precise and accurate RP-HPLC method has been developed and subsequently validated for simultaneous estimation of Aliskiren Hemifumarate and Nicardipine Besylate from their combination dosage form. Aliskiren and Nicardipine are widely used antihypertensive drugs at present but their analytical methods are very costly and very complex to simplify the methods with increasing sensitivity new methods were developed which are simple, precise, eco-friendly, less time consuming, rapid and fast and economically chief. First standard curve was plotted then the method is validated by using recovery studies, linearity, correctness and reproducibility, robustness, ruggedness, detection limit, quantification limits, stability studies etc. The validated technique has been with success used for stress testing analysis of Aliskiren and Nicardipine. The stress testing studies revealed that the tactic was with success utilized to resolve the degraded product from the sample. From the peak purity profile it had been demonstrated that there was no interference of degradation product and the purity of angle were found to be but the purity of threshold. This work was undertaken with an aim of developing HPLC and Specrophotometric techniques for analysis of Aliskiren and Nicardipine. Number of trials was taken for selection of column and M. Phase’. The proposed method was validated as per the ICH and USP guidelines.

Keywords: Aliskiren, nicardipine, RP-HPLC method, tablet dosage forms
PHARMACOSOMES: AN UPDATED REVIEW

PHARMACOSOMES: AN UPDATED REVIEW

Authors: Ali Gamal Ahmed Al-kaf, Ahmed Mohamed Othman
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Abstract

Different lipid based vesicular systems have been developed as controlled and targeted drug delivery systems. Pharmacosomes are novel vesicular drug delivery systems. They are potential alternative to conventional vesicles. Pharmacosomes are the amphiphilic phospholipids complexes of drugs bearing active hydrogen that bind to phospholipids. Similar to other vesicular systems pharmacosomes provide an efficient method for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects. They also reduces the cost of therapy by improving bioavailability of medication, especially in the case of poorly soluble drugs. This approach as a drug delivery system certainly promises a reliable, safe, selective and precise method of drug delivery. They help in controlled release of drug at the site of action as well as in reduction in cost of therapy, drug leakage and toxicity, increased bioavailability of poorly soluble drugs, and restorative effects. They are mainly prepared by hand-shaking and ether injection method. The Pharmacosomes have evaluated for different parameters such as size, surface morphology and in vitro release rate. This article reviews the potential of pharmacosomes as a controlled and targeted drug delivery systems and highlights the methods of preparation and characterization.

Keywords: Pharmacosomes, amphiphilic, targeted drug delivery system, biosomes, phospholipids, bioavailability
PREPARATION AND CHARACTERIZATION OF TOLTERODINE TARTRATE PRONIOSOMES

PREPARATION AND CHARACTERIZATION OF TOLTERODINE TARTRATE PRONIOSOMES

Authors: Adim Ekene Ugochukwu, Obeta Judith Nnedimkpa, Ngwu Ogochukwu Rita
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Abstract

The present work deals with the preparation of Tolterodine tartrate proniosome formulations by ether injection method by using different surfactants in different ratios. The prepared proniosomal formulation were evaluated for vesicle size, rate of spontaneity, encapsulation efficiency, drug content etc. In vitro release study was conducted and it indicated that, increases in liphophilicity of surfactants decreases release of Tolterodine tartrate from proniosomal formulations. Stability studies were performed at optimized formulation PG4, indicated that, the prepared formulations remain stable at room and refrigeration temperature.

Keywords: Tolterodine tartrate, proniosome, Span 60, Tween 40, in vitro release
DEVELOPMENT AND EVALUATION OF ALBENDAZOLE MICROCAPSULE FOR COLONIC DRUG DELIVERY SYSTEM

DEVELOPMENT AND EVALUATION OF ALBENDAZOLE MICROCAPSULE FOR COLONIC DRUG DELIVERY SYSTEM

Authors: Onyeka Ifeanyi Peter, Ukwe Chioma Ifeoma
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Abstract

At present scenario colon specific drug delivery has gained increased importance. Colon drug delivery system not only used for the treatment of local diseases, associated with the colon but also it is a potential site for systemic delivery of therapeutic drug. Albendazole is a benzimidazole carbamate broad spectrum oral anthelmetic drug. It is poorly water soluble and it undergoes extensive metabolism in the intestine and liver. Different batches of Albendazole microcapsules were prepared using different concentration of polymers like Eudragit RS-100, chitosan, HPMC. The microcapsules were then evaluated for micromeritic properties, percentage yield, incorporation efficiency, drug content. In vitro dissolution profile of each formulation was determined by employing USP XXIII rotating basket method.

Keywords: Albendazole, colon specific, eudragit, microcapsules
DEVELOPMENT AND EVALUATION OF RITONAVIR HOLLOW MICROBALLOONS FOR FLOATING DRUG DELIVERY

DEVELOPMENT AND EVALUATION OF RITONAVIR HOLLOW MICROBALLOONS FOR FLOATING DRUG DELIVERY

Authors: Uroko Robert Ikechukwu, Dingwoke Emeka John Francis, Ambi A A
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Abstract

Ritonavir is human immunodeficiency virus (HIV) protease inhibitor used as the antiretroviral agent. The objective of the present investigation was to formulate and evaluate Ritonavir gastro-retentive floating microballoons for controlled release. Different batches of microballoons were prepared by the emulsion solvent diffusion method. The resultant microballoons were evaluated for percentage yield, entrapment efficiency, particle size, and in vitro drug release, stability study. The densities of floating microspheres were found to be less than the density of gastric fluid (1.004 g/cm3). The entrapment efficiency of prepared floating microspheres was satisfactory (68.37 to 88.52%). Among all formulations, FM1 prepared with polymer HPMC was found to be the best as it exhibited highest drug release (89.07%) in 12 hrs and was stable for three months at ambient conditions.

Keywords: Floating drug delivery, gastro-retentive, hollow microballoons, in vitro drug release, Ritonavir
ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM

ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM

Authors: Edenta Chidi, Nwobodo Ndubuisi Nwobodo, Nweje-Anyalowu Paul C
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Abstract

Gongronema latifolium (Asclepiadiaceae) is used as bitter spice or flavouring agent in many traditional Nigerian dishes. It is well known for medicinal and nutritional purposes like anti-hyperglycemic, anti-oxidant, antitussive and widely distributed in the southeastern states of Nigeria. Objective of present study was to evaluate the anti-hyperglycemic and anti-oxidant effect of the methanol extract of Gongronema latifolium leaves. The methanol extract of G. latifolium at doses of 250 and 500 mg/kg were studied for anti-hyperglycemic effect in alloxan-induced hyperglycemic rats. The variation in blood glucose level in normal and experimental rats on 0, 7, 14 and 21 days of treatment has also been recorded. Treatment with G. latifolium extract showed signs of recovery as comparable with the standard drug glibenclamide (0.25 mg/kg). The effect of different treatment on body weight of rats was also determined. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay. The result showed that G. latifolium extract caused a concentration dependent percentage increase of antioxidant activity. Study concludes that methanol leaf extract of G. latifolium possesses significant anti-hyperglycemic and anti-oxidant activities.

Keywords: Anti-hyperglycemic, anti-oxidant, carrageenan-induced paw edema, Gongronema latifolium

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