DEVELOPMENT AND EVALUATION OF RITONAVIR HOLLOW MICROBALLOONS FOR FLOATING DRUG DELIVERY
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 2
Abstract
Ritonavir is human immunodeficiency virus (HIV) protease inhibitor used as the antiretroviral agent. The objective of the present investigation was to formulate and evaluate Ritonavir gastro-retentive floating microballoons for controlled release. Different batches of microballoons were prepared by the emulsion solvent diffusion method. The resultant microballoons were evaluated for percentage yield, entrapment efficiency, particle size, and in vitro drug release, stability study. The densities of floating microspheres were found to be less than the density of gastric fluid (1.004 g/cm3). The entrapment efficiency of prepared floating microspheres was satisfactory (68.37 to 88.52%). Among all formulations, FM1 prepared with polymer HPMC was found to be the best as it exhibited highest drug release (89.07%) in 12 hrs and was stable for three months at ambient conditions.
Authors and Affiliations
Uroko Robert Ikechukwu, Dingwoke Emeka John Francis, Ambi A A
Keywords
Related Articles
- EP ID EP36383
- DOI https://doi.org/10.22270/ujpr.v2i2.R3
- Views 303
- Downloads 0
DENDRIMERS: A NOVEL TOOL FOR DRUG DELIVERY AND TARGETING
Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. Due to their unique architecture these have improved physical and chemical prope...
SERUM POSITIVITY OF ANA AND ASMA AMONG KHAT AND NONKHAT CHEWERS AS MARKERS FOR AUTOIMMUNE HEPATITIS TYPE 1
Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology. It has been proposed that certain herbs such as black cohosh and dai-saiko might trigger AIH. Khat is an ever green tree whose leaves h...
FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE
Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study...
COMPARISON OF THE KNOWLEDGE, ATTITUDE AND PERFORMANCE OF HOSPITAL MANAGERS IN BUSHEHR PROVINCE ABOUT NOSOCOMIAL INFECTIONS
Nosocomial infections are one of the social and economic medical problems in developing countries, which contribute to the spread of infectious diseases and long hospitalization and mortality among patients. The aim of t...
HYPOGLYCEMIC AND LIPID LOWERING EFFECT OF AQUEOUS FRESH LEAF EXTRACT OF CHROMOLAENA ODORATA (LINN) IN ALBINO WISTAR RATS FED DIFFERENT CONCENTRATIONS OF CHOLESTEROL ENRICHED DIET
High lipids and carbohydrate have been seriously implicated to cardiovascular problems, which has led to several uses of medicinal plants for traditional remedies. The present study investigated the lipid lowering activ...