RECENT TRENDS OF POLYMER USAGE IN THE FORMULATION OF ORODISPERSIBLE TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Disintegrants are an essential component to tablet formulations. While rapidly disintegrating tablets do not necessarily ensure fast bioavailability, slowly disintegrating tablets almost always assure slow bioavailability. The ability to interact strongly with water is essential to disintegrant function. Combinations of swelling and/or wicking and/or deformation are the mechanisms of disintegrant action. Super disintegrants offer significant improvements over starch. But hygroscopicity may be a problem in some formulations. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegration remains a powerful influence and precursor for drug absorption. Disintegration of tablet or capsule is depending upon the type and quantity of disintegrants. The development of Orodispersible tablets provides an opportunity to take an account of tablet disintegrants. Therefore, there is a huge potential for the evaluation of new disintegrants or modification of an existing disintegrants into superdisintegrants, so as to formulate Orodispersible tablets. The present study comprises the various kinds of disintegrants and superdisintegrants, which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance.
Authors and Affiliations
J. Preethi, MD Farhana, B. Chelli Babu, MD. Faizulla, Debjit Bhowmik, S. Duraivel
Keywords
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