A comparative study between propofol and thiopentone for hemodynamic parameters during induction of general anesthesia in surgical patients
Journal Title: Journal of Medical and Allied Sciences - Year 2017, Vol 7, Issue 1
Abstract
Hemodynamic stability is very much important during induction of general anesthesia. So, this study was planned to compare hemodynamic parameters during induction by thiopentone and propofol. This prospective study was conducted after approval from institutional ethics committee in non-hypertensive patients of ASA grade I and II aged between 18-60 yrs of either sex, admitted for different surgical procedure. The patients were randomized into group P (propofol) and group T (thiopentone). Heart rate, both systolic (SBP) and diastolic blood pressure (DBP) were recorded during induction and at 1 minutes, 2 minutes, 3 minutes and 4 minutes interval after intubation. Thirty patients in each group were included during study period. After induction, there was fall in both mean SBP and DBP after an increase during intubation which was more in group T (p˂0.05). The statistically significant difference was observed only at 1min between two groups for SBP (P value <0.05). The mean heart rate was almost similar at pre induction time in both the groups (p>0.05). There was rise in heart rate during intubation in both the groups, thereafter heart rate started decreasing. The fall was similar in both the group at any given point of observation (P value >0.05). Both propofol and thiopentone alter the blood pressure and heart rate during induction in surgical patients which are more pronounced in thiopentone but these changes return close to baseline value earlier in case of propofol. So, propofol could be the preferred inducing agent in hemodynamically unstable patients.
Authors and Affiliations
Rakesh Kushwaha| Department of Anesthesiology & Critical Care, Pacific Institute of Medical Sciences, Umarda, Udaipur- 313003, Rajasthan, India, Savita Choudhary| Department of Anesthesiology & Critical Care, Geetanjali Medical College & Hospital, Udaipur-313002, Rajasthan, India
ACE I/D gene polymorphism in diabetic nephropathy: Clinical implications
Diabetic nephropathy (DN) is a major microvascular complication accounting for about 30% of End-Stage Renal Disease (ESRD) cases. An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-I converting e...
Simultaneous detection of Hepatitis B virus and Hepatitis C virus in human plasma using Taq-man chemistry
Designing a rapid, reliable and sensitive assay, for detection of hepatitis B virus and Hepatitis C virus variants by real-time PCR, is challenging at best. A recent approach for quantifying the viral load using the s...
Falciparum malaria associated changes in biochemical indices in children
Metabolic disturbances associated with fluid and electrolyte imbalance, and changes in the synthetic functions of the liver are common complications of malaria and are dependent on the degree of parasitemia. Packed cel...
Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride
Fluoride is known to cross the blood-brain barrier and alter the structure and function of neural tissue. There are few authoritative reports on neurodegenerative changes in hippocampus, neocortex, cerebellum, spinal...
Comparison of conventional diagnostic modalities, BACTEC culture with polymerase chain reaction for diagnosis of extra-pulmonary tuberculosis
This study attempts to determine and compare the sensitivity, specificity and turnaround time of conventional diagnostic modalities, BACTEC culture and polymerase chain reaction test for diagnosis of extra-pulmonary tub...