A comparative study between propofol and thiopentone for hemodynamic parameters during induction of general anesthesia in surgical patients
Journal Title: Journal of Medical and Allied Sciences - Year 2017, Vol 7, Issue 1
Abstract
Hemodynamic stability is very much important during induction of general anesthesia. So, this study was planned to compare hemodynamic parameters during induction by thiopentone and propofol. This prospective study was conducted after approval from institutional ethics committee in non-hypertensive patients of ASA grade I and II aged between 18-60 yrs of either sex, admitted for different surgical procedure. The patients were randomized into group P (propofol) and group T (thiopentone). Heart rate, both systolic (SBP) and diastolic blood pressure (DBP) were recorded during induction and at 1 minutes, 2 minutes, 3 minutes and 4 minutes interval after intubation. Thirty patients in each group were included during study period. After induction, there was fall in both mean SBP and DBP after an increase during intubation which was more in group T (p˂0.05). The statistically significant difference was observed only at 1min between two groups for SBP (P value <0.05). The mean heart rate was almost similar at pre induction time in both the groups (p>0.05). There was rise in heart rate during intubation in both the groups, thereafter heart rate started decreasing. The fall was similar in both the group at any given point of observation (P value >0.05). Both propofol and thiopentone alter the blood pressure and heart rate during induction in surgical patients which are more pronounced in thiopentone but these changes return close to baseline value earlier in case of propofol. So, propofol could be the preferred inducing agent in hemodynamically unstable patients.
Authors and Affiliations
Rakesh Kushwaha| Department of Anesthesiology & Critical Care, Pacific Institute of Medical Sciences, Umarda, Udaipur- 313003, Rajasthan, India, Savita Choudhary| Department of Anesthesiology & Critical Care, Geetanjali Medical College & Hospital, Udaipur-313002, Rajasthan, India
Keywords
Related Articles
- EP ID EP12755
- DOI 10.5455/jmas.247007
- Views 364
- Downloads 23
Heterotaxy syndrome with associated agenesis of dorsal pancreas and polysplenia: A case report
Heterotaxy syndrome is a rare embryological disorder comprising of polysplenia, partial agenesis of dorsal pancreas, malrotation of gut, cardiac and vascular anomalies resulting from failure of development of the usual...
Bilateral pleuropulmonary blastoma (PPB) in a 2- year-old girl: A case report with review of literature
Pleuropulmonary blastoma (PPB) is a rare aggressive malignant tumor of infancy and early childhood accounting for 0.25-0.5% of primary lung tumors. PPB is a dysontogenic tumor composed of immature malignant epithelial a...
Lobular capillary hemangioma of esophagus mimicking Barrett’s esophagus
A 30 year old male patient presented to the outpatient department of Gastroenterology with complaints of dyspepsia of 6 months duration associated with progressive dysphagia to solids and liquids. There was no noticeab...
Hydatid cyst of lung and liver: Single stage management
A 30 year female presented with history of pain abdomen, abdominal distension since six months, diagnosed to have huge hydatid cysts both in right lung and liver. It is unusual to find such large cysts at multiple site...
Mixed variant calcinosis cutis
A 7 year old boy presented with multiple, raised, hard nodules of varying sizes over both elbows and right knee and small milia like lesions over the chin. Serum levels of calcium, phosphorus and uric acid were normal...