A New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite
Journal Title: Journal of Biomedical Physics and Engineering - Year 2019, Vol 9, Issue 2
Abstract
Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent. Material and Methods: Iron oxide–4A nanocomposite (F4A) was synthesized. MTT assay was used to consider the nanocomposite safety for cell culture. The T1 and T2 relaxation times were measured using a 1.5 Tesla clinical MRI scanner. Then the corresponding relaxivities were determined. Results: The average particle diameter of the nanocomposite was 50 to 100 nm based on scanning electron microscope (SEM) image. A linear relationship between relaxation rates and the Fe concentration of the nanocomposite was obtained. The T1 and T2 relaxivities of the nanocomposite were calculated 5.413 and 1092.1 mM-1.s-1, respectively which led to the T2/T1 relaxivity ratio of 201.75. Conclusion: The high T2/T1 relaxivity ratio of the iron oxide–4A nanocomposite confirms it’s potential to act as a T2 contrast agent.
Authors and Affiliations
N. Gharehaghaji, L. Zareei, B. Divband, A. Mesbahi, M. Khatamian
Keywords
Related Articles
- EP ID EP613511
- DOI -
- Views 108
- Downloads 0
Dynamic MLC Tracking Using 4D Lung Tumor Motion Modelling and EPID Feedback
Background: Respiratory motion causes thoracic movement and reduces targeting accuracy in radiotherapy. Objective: This study proposes an approach to generate a model to track lung tumor motion by controlling dynamic mul...
Evaluation of Breast Cancer Radiation Therapy Techniques in Outfield Organs of Rando Phantom with Thermoluminescence Dosimeter
Background: Given the importance of scattered and low doses in secondary cancer caused by radiation treatment, the point dose of critical organs, which were not subjected to radiation treatment in breast cancer radiother...
Blocking Short-Wavelength Component of the Visible Light Emitted by Smartphones’ Screens Improves Human Sleep Quality
Background: It has been shown that short-wavelength blue component of the visible light spectrum can alter the circadian rhythm and suppress the level of melatonin hormone. The short-wavelength light emitted by smartphon...
Is Telomere Length a Biomarker of Adaptive Response in Space? Curious Findings from NASA and Residents of High Background Radiation Areas
Telomere length and stability is a biomarker of aging, stress, and cancer. Shortening of telomeres and high level of DNA damages are known to be associated with aging. Telomere shortening normally occurs during cell divi...
The Optimization of Magnetic Resonance Imaging Pulse Sequences in Order to Better Detection of Multiple Sclerosis Plaques
Background and Objective: Magnetic resonance imaging (MRI) is the most sensitive technique to detect multiple sclerosis (MS) plaques in central nervous system. In some cases, patients who were suspicious of having MS wh...