Detection and Characterization of Human Teeth Caries Using 2D Correlation Raman Spectroscopy
Journal Title: Journal of Biomedical Physics and Engineering - Year 2019, Vol 9, Issue 2
Abstract
Background: Carious lesions are formed by a complex process of chemical interaction between dental enamel and its environment. They can cause cavities and pain, and are expensive to fix. It is hard to characterize in vivo as a result of environment factors and remineralization by ions in the oral cavity. Objectives: The development of a technique that gives early diagnosis which is non-invasive, is of crucial importance for publichealth. Raman spectroscopy is a technique that can fulfil these requirements. The main goal of this work was to use Raman spectroscopy to differentiate between normal and carious human teethinvivo. The samples used in this study were collected by traditional human teeth. Material and Method: An in vivo Raman spectroscopy system andspecialized fiber optic probe has been designed to obtain spectra from tissue. Theseprobes are filtered to reduce the background signal from the fiber optics and the collection fiberutilizes beam steering to optimize the collection effectiv. Results: In order to detect any demineralization and carious versus sound pit and fissure enamel, the spectral data sets are analyzed by the proposed scheme to demonstrate the utility of generalized 2D correlation spectra. Potential applications of this 2D correlation approach are then explored. The Raman spectra in the normal tissue showed thepresence of vibrational bands in 437.87 cm-1, 581.89 cm-1, 953.89 cm-1 and 1054.73 cm-1 with smaller intensity than in the carious spectra. Image construction from the peak intensity produced chemical maps of apatite concentration. Conclusion: Such two-dimensional correlation spectra emphasize spectral features not readily observable in conventional one-dimensional spectra.No correlation is observed in mode-to-mode intensity fluctuations indicating that the changes inmode intensities are completely independent. Theoretical calculations provide convincing evidence that the fluctuationsare not the result of diffusion, orientation or local electromagnetic field gradients but rather are the result of subtle variations ofthe excited-state lifetime, energy and geometry of the molecule and producing a signature response for carious detection.
Authors and Affiliations
Y. H. El-Sharkawyi
Keywords
Related Articles
- EP ID EP613425
- DOI -
- Views 131
- Downloads 0
Alzheimer ’s Disease: Possible Mechanisms Behind Neurohormesis Induced by Exposure to Low Doses of Ionizing Radiation
In 2016, scientists reported that human exposure to low doses of ionizing radiation (CT scans of the brain) might relieve symptoms of both Alzheimer’s disease (AD) and Parkinson disease (PD). The findings were unbelievab...
Dose Calculation Accuracy of Radiotherapy Treatment Planning Systems in Out-of-Field Regions
NO ABSTRACT
Evaluation of Electron Specific Absorbed Fractions in Organs of Digimouse Voxel Phantom Using Monte Carlo Simulation Code FLUKA
Background: For preclinical evaluations of radiopharmaceuticals, most studies are carried out on mice. Electron specific absorbed fractions (SAF) values have had vital role in the assessment of absorbed dose. In past stu...
Synergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP Cells
Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often oc...
Use of Magnetic Resonance Imaging in Food Quality Control: A Review
ABSTRACT Modern challenges of food science require a new understanding of the determinants of food quality and safety. Application of advanced imaging modalities such as magnetic resonance imaging (MRI) has seen impressi...