A novel liquid oral formulation for 1- Octacosanol an anticancer drug and its stability study
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 3
Abstract
1-Octacosanol is a long chain fatty acid alcohol and a liphophilic waxy compound and hence by nature it is insoluble in water. Therefore, the respective drug active encounters a challenge of active absorption in the clinical settings. Thus, a necessity for the development of water soluble, a bio absorbable and a palatable formulation for 1- Octacosanol was addressed in this study. Apart from this, a secondary objective of presenting this drug product to pediatric and geriatric patients in a palatable manner, in order to increase their compliance. Various galenical feasibility studies were conducted to identify the specific ingredients and its respective proportion to bring out the desired emulsion. The resultant formulation facilitates the increased bioavailability; herewith we disclose a novel liquid oral emulsion formulation. It is a liquid oral emulsion dosage form of oil in water type, containing adjutants like Corn oil, Tween -80, Span-60, Sucralose, Flavour (raspberry), Water (DM), Simethicone, Methyl paraban, Propyl paraban etc. The final product exhibit a milky white emulsion, was further tested for its physical stability and its palatability through numerous experiments.
Authors and Affiliations
Shaji KP, Umesha S, Bharathi P Salimath
Keywords
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