A Prospective Study on The Pattern of Hepatic Enzymes After Abstinence In Alcohol Dependence Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
BACKGROUND: All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder.Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean corpuscular volume, gamma-glutamyltranspeptidase, and A:G ratio . AIM: To study the pattern of Hepatic enzymes after abstinence among alcohol dependent patients MATERIALS AND METHODS: : A prospective study on all patients with alcohol dependence attending de addiction centre.A total of 118 patients have been enrolled in the study. Serum biomarkers SGOT {AST} and SGPT (ALT) were analysed at 0,15,30, 60 90 and 180 days RESULTS: Mean age in years of the study population is 38.5 years. Mean age of alcohol intake is 21.3 years. Mean duration of alcohol intake is 17.2 years The mean value of AST/ALT ratio was found to be 1.09 with a range of 0.59 to 1.62. In the present study the mean AST levels come down with the increase in the duration of abstinence. CONCLUSIONS: Majority of the subjects reached normal range of AST levels after 30 days of abstinence. Nearly 60% of them reached normal ALT levels after 60 days of abstinence. The AST levels will reach earlier to normal levels when compared to ALT levels in abstinence of Alcohol.
Authors and Affiliations
Dr. N. Annapurna, Dr. Madhavi Latha Kalla
Keywords
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- EP ID EP395515
- DOI 10.9790/0853-1709120112.
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