A Study of Prognostic Value of HbA1C in Non-Diabetic Patients of Acute Coronary Syndrome
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Patients with diabetes mellitus have a poorer outcome after acute coronary syndrome (ACS) than the general population.Objective of the study was to access the prognostic value of HbA1C in non-diabetic patients of acute coronary syndrome Material and Methods: This observational cross sectional study included 110 patients without diabetes mellitus who were admitted to the ICU with symptoms suggestive of ACS. The diagnosis of ACS was made on the basis of troponin T value, ECG and echocardiograph. Patients were stratified according to their HbA1c into two groups: Group 1 HbA1c <5.6 (36, 36%), group 2 HbA1c between 5.7 and 6.4 (64,64%). Main outcome measures were ECG changes, trop T value, RWMA and left ventricular ejection fraction (LVEF) on echo, along with the complications like heart failure and arrhythmias. Data was analyzed separately using multiple regression analysis Results: The mean age of patients was 58.67 years out of which 69% were males and 31% females. Of total, 28% were smokers, 33% were known to be hypertensive, 32% had dyslipidemia and BMI was ≥ 25 kg/ m2 in 9% of the subjects. 91 cases out of 110 were positive for presence of RWMA on ECHO. In this, 70 patients had high normal HAb1C and 40 patients had normal HAb1C. Even the percentage of heart failure in high normal HbA1c level patients, was 64.75% as compared to 34.25% in normal HbA1c level patients. Conclusion: HAb1C seems to be predictor of adverse results in acute coronary syndrome in patients without diabetes. Assessment of HbA1c levels may improve risk assessment in such patients when presenting with ACS.
Authors and Affiliations
G. Vijay Kumar, Madhavi Latha, Z. Naveen Kumar
Keywords
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