Adverse Drug Reactions to First Line Anti-Tubercular Drugs - A Pharmacovigilance Study
Journal Title: International Journal of Pharmacological Research - Year 2016, Vol 6, Issue 2
Abstract
Introduction: Tuberculosis is one of the major health problems in India and developing countries. It is the second leading infectious cause of morbidity and mortality in the world. Objective: The present study was undertaken to study the Adverse Drug Reactions (ADRs) to first line Anti-tubercular drugs (ATTs) prescribed to tuberculosis patients admitted to Medicine Department, BTGH, attached to M.R. Medical College, Gulbarga. Materials and Methods: A Prospective Observational study was carried among tuberculosis patients on Directly Observed Short Course Chemotherapy (DOTS), admitted to Medicine Department, BTGH, attached to M.R. Medical College; Gulbarga.120 Patients were included during the study period of 9 months from 1st October 2014 to 30th June 2015. The data was collected in a Proforma which included questionnaire. Results: A total of 120 tuberculosis patients on DOTS were enrolled for the study. Out of 107 patients, 63 patients (58.87%) developed ADRs. Out of 63 patients, 32 patients (51%) developed Gastro-intestinal problems, 14 patients developed CNS problems (22%), 11 patients (18%) developed Hepatitis, 4 patients (6%) developed Fever and 2 patients (3%) developed Pancreatitis. The most serious ADR was Hepatitis. Conclusion: Results of the study reveals that about 58.87% of patients developed ADRs during the study period. These ADRs will lead to stoppage of drugs, development of Drug resistance and Therapeutic Failure. If a proper Pharmacovigilance system is implemented in the hospital, most of the patients may report their ADRs and thereby we can improve the patient adherence and treatment outcome.
Authors and Affiliations
Umeshchandra C Honnaddi, Madhushalini U Honnaddi, Tharangini SR, Taher Hossain, Roopali Somani
Keywords
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- EP ID EP435228
- DOI 10.7439/ijpr.v6i2.2899
- Views 55
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