Preclinical Safety Evaluation Of Aqueous Bark Extract Of Saraca Asoca Roxb : Acute And Subacute Oral Toxicity
Journal Title: International Journal of Pharmacological Research - Year 2015, Vol 5, Issue 12
Abstract
The present study was aimed to investigate the potential toxicity of the aqueous extract of the stem bark of Saraca asoca (SA) in Wistar rats following the OECD guidelines. In acute oral toxicity, female rats received a single dose of 2000 mg/kg of SA and were observed for 14 days. In sub-acute toxicity, doses of 250, 500, 1000 mg/kg/day of SA were administered to rats (males and females) for 28 days. No mortality rate was found in acute toxicity testing but some behavioural changes were recorded in animals. In sub-acute oral toxicity no significant changes in body weight, body temperature, food and water consumption and urine parameters were observed. However, significant alterations in haematological and serum biochemical parameters were noticed in animals receiving higher doses. A significant variation in relative organ weight of liver, spleen and kidney was observed in all test groups of 28 day and 90 day repeated dose oral toxicity testing. Such variation was dose dependent and hence, the present toxicity study indicates that orally administered aqueous bark extract of Saraca asoca may have some toxic effects.
Authors and Affiliations
Nutan Balkrishna Chaudhari, Anupama Suralkar, Ziyaurrahman AR
Keywords
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- EP ID EP434947
- DOI 10.7439/ijpr.v5i12.2791
- Views 80
- Downloads 0
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