Allogeneic hematopoietic cell transplantation in refractory Hodgkin’s lymphoma cases, the chance for long-term remission
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 9
Abstract
The role of allogeneic hematopoietic cell transplantation (alloHSCT) in the treatment of Hodgkin’s lymphoma is still debated.<br>In Department of Hematology and BMT Medical University of Silesia, among the 390 hematopoietic cell transplantations in Hodgkin’s lymphoma patients (pts), 7 pts with refractory or relapsed HD (median age 22), who had the full matched sibling donor, were undergone alloHSCT, two of them twice time. Each patient received at least three lines of chemotherapy. Two pts were undergone autologous hematopoietic cell transplantation before alloHSCT. At the time of alloHSCT 1 pts was in complete remission, 4 were in partial remission and 4 during active phase of the disease. Non-myeloablative conditioning regimens preceding alloHSCT were used.<br>Due to alloHSCT one patient died (TRM 22%). Hematopoietic recovery after alloHSCT was: ANC > 0.5 x 10^9/L after median of 22 days and platelet > 50 x 10^9/L after 21 days. Two pts had to undergo second alloHSCT, because of relapse for the first, and the second one because of lack of engraftment.<br>4 pts died due to progression or early relapse. Two pts are still alive (both with chronic graft versus host disease); one survived longer than 10 years in CR and the other one survived 21 months in PR. The median time of survival is 21 months (4-120).<br><b>Conclusions. </b>AlloHSCT with non-myeloablative conditioning regimen in patient with relapsed or refractory Hodgkin’s lymphoma could be considered as a treatment option for a patient with full matched sibling donor and can be an opportunity to extend the life of these patients.
Authors and Affiliations
Małgorzata Krawczyk-Kuliś, Anna Kopińska, Mirosław Markiewicz, Sławomira Kyrcz-Krzemień
Keywords
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