AN EXPERIMENTAL STUDY OF THE TOXICITY EFFECTS OF CALOTROPIS PROCERA (AITON) ASCLEPIADACEAE IN SPRAGUE-DAWLEY RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 9
Abstract
Calotropis procera Aiton (Calotropis) is a wild-growing plant used for a variety of disease conditions such as leprosy, ulcers, tumor and healing of wounds. The present study was conceived to evaluate the toxicological effect of the latex following systemic use in Sprague-Dawley rats with a view to understanding its potential safety in treating wounds and preventing keloid formation in human. Haematological evaluation revealed a significant and progressive reduction of the packed cell volume (PCV) and red blood cell count at high doses of the latex. There was no significant effect on the differential count except for lymphocytes which showed significant reduction following increasing concentrations of the latex. Similarly, the latex exhibited no significant effect on the renal indices of the rats: uric acid, urea and creatinine levels. A significant (P<0.05) decrease in blood glucose was observed in the group that received 0.85mg/kg of the latex as compared with the control. The latex produced a significant (p < 0.05) decrease in the levels of aspartate transaminases at a dose of 0.35mg/kg IP and also the level of total cholesterol had a significant (p<0.05) decrease at the same dose, but there was no significant change in the levels of the albumin, alanine transaminases and alkaline phosphatases in all the treated groups. Histopathological studies showed no remarkable effect on the tested organs except for the testes where there was destruction of the seminiferous tubules. In conclusion, these results suggest that Calotropis latex is relatively safe when used acutely especially through the oral route and in lower doses when administered through the intra-peritoneal route in rats. However, there is need for caution when higher doses are administered because of the toxic effects on the genitourinary systems particularly in males.
Authors and Affiliations
Adebimpe O. A. Aderounmu (Prof)
Keywords
Related Articles
- EP ID EP673670
- DOI -
- Views 184
- Downloads 0
IMPROVED ORAL GLUCOSE TOLERANCE WITH METHANOL EXTRACT OF MUSA TEXTILIS NEE AND SYNERGISTIC ACTION WITH GLIBENCLAMIDE
Background: In previous studies we have observed that methanol extracts of fruit skins of various types of cultivated banana species (Musa sapientum and Musa seminifera) can improve glucose tolerance in glucose-loaded mi...
IMPROVED GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF COLOCASIA ESCULENTA TUBERS AND ALLIUM SATIVUM CLOVES
Background: Colocasia esculenta and Allium sativum are cultivated in Bangladesh, respectively, for consumption of tubers as vegetable and use of cloves as spice. Both plant parts have previously been reported to have ant...
THYMELAEA MICROPHYLLA AMELIORATES OXIDATIVE STRESS AND METALLOTHIONEIN LEVEL INDUCED BY CADMIUM IN RAT KIDNEY
Background and Objective: The present investigation was performed to evaluate the protective effect and the antioxidant power of Thymelaea microphylla against cadmium chloride induced oxidative stress and renal toxicity...
ETHNOBOTANY AND PHYTOCHEMICAL OF ABUTILON INDICUM (LINN.) SWEET: A REVIEW
Abutilon indicum (Linn.) is belongs to family Malvaceae. The whole plant or its specific parts (leaves, stem, roots, fruits and seeds) are known to have medicinal properties and have a long history of use by indigenous a...
SYNTHESIS AND SPECTRAL CHARACTERIZATION OF SOME TRANSITION METAL COMPLEXES OF AZO-SCHIFF BASE DERIVATIVE OF METOCLOPRAMIDE
A new Azo-Schiff base ligand L was prepared by reaction of azoaldehyde with Metoclopramide (2-(diethylamino)ethyl 4- aminobenzoate). This synthesized ligand was used for complexation with different metal ions like Ni (II...