An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses
Journal Title: International Journal of Bioprinting - Year 2018, Vol 4, Issue 1
Abstract
Bone repair failure caused by implant-related infections is a common and troublesome problem. In this study, an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide (nMgO) to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The results indicated the scaffold exerted high antibacterial activity. The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species (ROS) and direct contact action, respectively, which resulted in the damage of their structures and functions. Besides, nMgO significantly increased the compressive properties of the scaffold including strength and modulus, due to its excellent mechanical properties and uniform dispersion in the PHBV matrix. Moreover, the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold. The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation, as well as osteogenic differentiation. The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering.
Authors and Affiliations
Cijun Shuai, Wang Guo, Chengde Gao, Youwen Yang, Ping Wu and Pei Feng
Keywords
Related Articles
- EP ID EP678676
- DOI -
- Views 152
- Downloads 0
3D food printing—An innovative way of mass customization in food fabrication
About 15%–25% of the aging population suffers from swallowing difficulties, and this creates an increasing market need for mass customization of food. The food industry is investigating mass customization techniques to m...
Fabrication of titanium based biphasic scaffold using selective laser melting and collagen immersion
Tissue engineering approaches have been adopted to address challenges in osteochondral tissue regeneration. Single phase scaffolds, which consist of only one single material throughout the whole structure, have been used...
Bioprinting of artificial blood vessels
Vascular networks have an important role to play in transporting nutrients, oxygen, metabolic wastes and maintenance of homeostasis. Bioprinting is a promising technology as it is able to fabricate complex, specific mult...
A new design of an electrospinning apparatus for tissue engineering applications
The electrospinning technique is being widely explored in the biomedical field due to its simplicity to produce meshes and its capacity to mimic the micro-nanostructure of the natural extracellular matrix. For skin tissu...
Artificial vascularized scaffolds for 3D-tissue regeneration — a report of the ArtiVasc 3D Project
The aim of this paper is to raise awareness of the ArtiVasc 3D project and its findings. Vascularization is one of the most important and highly challenging issues in the development of soft tissue. It is necessary to su...